An observational study in Sepsis, sponsored by Jens Rikardt Andersen. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-07-20.
Sponsored by Jens Rikardt Andersen · Observational
Surgery induces insulin resistance lasting for 2-3 weeks. We wanted to elucidate if stress-metabolic, medical conditions carry the same effect.
Background: Insulin resistance is well documented after surgery in a severity positively correlated to the degree of trauma (Thorell et al. 1999; Chambrier et al. 2000). Similar phenomena have been described in severely ill patients in ICU with consequences for the survival (Van den Berghe et al. 2001; The NICE-SUGAR Study Investigators 2009). The documentation, however, is scarce and the extent is unknown in acutely ill patients with sepsis.
Method: Adult, consecutive, non-diabetic patients with elevated CRP, leukocyte counts, SOFA-score of ≥ 2 were monitored with fasting p-C-peptide, blood glucose, CRP, leukocyte count and HOMA-IR at admittance, discharge and at two follow-up visits 2 weeks and 4 weeks after admission. Blood glucose levels were measured continuously during the whole study period with a flash glucose monitor mounted on the patients' upper arm. The diagnosis was sepsis, urosepsis, pneumonia, erysipecosis, bacteremia, infection with unknow focus and covid-19.
1,899 studies on the registry are indexed under Sepsis; 458 are open to participants now.
This study's enrollment of 18 is below the median of 160 across 929 observational studies indexed under Sepsis.
Browse Sepsis studies →Jens Rikardt Andersen is the lead sponsor of 23 studies on the registry; 1 is open to participants now.
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Consecutive adults acutely admnitted to hospital with diagnosed sepsis on bacterial basis or on basis of covid-19
Exclusion Criteria:
standard treatment in the clinical routine
continous blood glucose
flash glucose monitor on the upper arm
Time frame: 4 weeks
C-peptide
plasma concentration
Time frame: 4 weeks
HOMA-IR
calculated glucose load test
Time frame: 4 weeks
Plan to share: No — no plans
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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Jens Rikardt Andersen