An interventional study of Nitrate in Vasodilation and Coronary Artery Disease, sponsored by Inha University Hospital. Status unknown. Open to participants aged 19 Years to 90 Years. Per ClinicalTrials.gov, last updated 2021-06-18.
Sponsored by Inha University Hospital · Not applicable, Interventional, and Treatment
In patients with vasospasm or with negative remodeling, various vasodilator drugs used during coronary angiography can dilate the diameter of the reference vessel to measure the exact vessel size. In particular, nitrates are well known to induce pharmacological vasodilatory effects through vascular smooth muscle relaxation In actual clinical practice, it has been reported that when oral or spray-type nitrate preparations are administered to coronary artery stenosis lesions, the diameter of the reference vessel expands by about 10% compared to the existing vessel diameter. This may enable larger stenting in coronary artery stenosis lesions. Although many patients with vascular stenosis are accompanied by vasospasm and voice remodeling, in actual clinical practice, administration of vasodilators is only used in a small number of patients at the discretion of the surgeon. Nitrate vasodilators administered during coronary angiography are low-dose and short-acting drugs, and although a small number of patients may experience side effects such as short-term lowering of blood pressure, no serious side effects are reported .
On this background, this study is to evaluate whether there is a difference in the diameter of the Ultimaster® stent treated with the conventional method compared to the maximally dilated coronary artery, and to evaluate the stability and effectiveness after the procedure.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's planned enrollment of 400 is above the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Inha University Hospital is the lead sponsor of 37 studies on the registry; 8 are open to participants now.
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evidence of coronary artery disease including asymptomatic ischemia stable angina acute coronary syndrome (unstable angina, non-ST segment elevation
Exclusion Criteria:
with administration of intra-coronary nitrate before percutaneous coronary intervention
Drug: Nitrate
without administration of intra-coronary nitrate before percutaneous coronary intervention
Drug: Nitrate
Administration of intra-coronary nitrate before percutaneous coronary intervention
Also known as: No intervention
Mean stent diameter
Time frame: Immediately after percutaneous coronary intervention
Failure rate of target lesion for 1-year (combination of cardiac death, target vascular myocardial infarction, target vascular revascularization)
Time frame: 1 year after percutaneous coronary intervention
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
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Inha University Hospital