An observational study in Metabolic Syndrome, Meniscus Lesion and Obesity, Abdominal, sponsored by The First People's Hospital of Jingzhou. Completed at 1 site in China. Open to participants aged 35 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-06-10.
Sponsored by The First People's Hospital of Jingzhou · Observational
Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between obese patients with metabolic syndrome and degenerate meniscus lesions and its knee function.The aim is to detect the correlation between obese patients with metabolic syndrome and degenerate meniscus injuries.
Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between patients with metabolic syndrome and degenerate meniscus lesions or knee function. Participants were recruited from First Affiliated Hospital of Jinzhou Medical University. 100 BMI\<24 people without Metabolic syndrome volunteers aged between 35-70 years old and 80 Metabolic syndrome patients with BMI>27 were included in the study. Obese patients with MetS were assessed knee function and degenerate meniscus tears verified by magnetic resonance imaging. And patients with a mild or no osteoarthritis with Kellgren and Lawrence grade\<2 verified by X ray. We tested the relationship between metabolic syndrome and degenerate meniscus lesions. Obese patients with MetS and volunteers were detected by Mcmurry's test and MRI image to measure degeneration grade of meniscus tears. Number of MetS components were accounted and the knee function KOOS, IKDC score or degenerate meniscus tears were analyzed.
1,964 studies on the registry are indexed under Metabolic Syndrome; 329 are open to participants now.
This study's enrollment of 180 is close to the median of 200 across 458 observational studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →The First People's Hospital of Jingzhou is the lead sponsor of 6 studies on the registry; none are open to participants now.
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participants from Jinzhou City, west of Liaoning Province
Exclusion Criteria:
100 volunteers aged between 35-70 years old with body mass index(BMI)\<24 without Metabolic syndrome
80 Metabolic syndrome patients with BMI\>27 were included in the study
Other: Metabolic syndrome and meniscus injuries
Metabolic syndrome
the Knee injury and Osteoarthritis Outcome Score (KOOS) total
The Knee injury and Osteoarthritis Outcome Score (KOOS) holds five subscales including: Pain (9 items); other Symptoms (7 items); Activities of Daily Living (ADL, 17 items); Sport and Recreation function (Sport/Rec, 5 items); and knee-related Quality of Life (QoL, 4 items). Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems).
Time frame: up to 12 month
The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score
The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score to determine the meniscus function. The IKDC is a questionnaire that has high reliability and validity for patients with a meniscal tear\[36, 37\] \[38\]. The questionnaire contains 18 items (7 items for symptoms, 1 item for sport activity, 9 items for daily activities, and 1 item for current knee function.) The total score is transformed to a value on a scale of 0 to 100, with 100 representing the highest knee function and 0 is the worst.
Time frame: up to 12 month
KOOS Pain subscale
Pain including 9 items，The minimum value is 0 and maximum values subscale is 100, the scored separately from zero (extreme knee problems) to 100 (no knee problems)
Time frame: up to 12 month
Symptoms subscale
Symptoms including 7 items,The minimum value is 0 and maximum values subscale is 100. Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems)
Time frame: up to 12 month
Activities of Daily Living subscale
Activities of Daily Living including 17 items,The minimum value is 0 and maximum values subscale is100. Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems).
Time frame: up to 12 month
Sport and Recreation function subscale
Sport and Recreation function including 5 items,The minimum value is 0 and maximum values subscale is 100. Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems).
Time frame: up to 12 month
knee-related Quality of Life subscale
knee-related Quality of Life including 4 items,The minimum value is 0 and maximum values subscale is 100. Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems).
Time frame: up to 12 month
KOOS4
KOOS4, The minimum value is 0 and maximum values subscale is100. KOOS4 defined as the average score for four of the five knee injury and osteoarthritis outcome score (KOOS) validity for patients with meniscal tears and osteoarthritis.
Time frame: up to 12 month
Plan to share: Undecided
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This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
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The First People's Hospital of Jingzhou