An observational study in Noninvasive Ventlation, COVID-19 Respiratory Infection and Diaphragm Injury, sponsored by Azienda Ospedaliera di Perugia. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-05-27.
Sponsored by Azienda Ospedaliera di Perugia · Observational
The present investigation aims to assess the diaphragmatic thickening fraction, reflecting the diaphragmatic activity, during supine (baseline) and at 1 hour following prone position in patients assisted through non invasive ventilation due to hypoxemic acute respiratory failure related to COVID-19. Also, the impact of lung aeration and comfort were ascertained in the same setting
Primary aim is to asses the effects of body position on diaphragmatic thickening fraction (primary aim) and lung aeration and vital sign (secondary aims) in patents assisted via noninvasive ventilation (NIV) for hypoxemic acute respiratory failure (hARF) associated to COVID-19. All adult patients, admitted for hARF due to COVID-19 and requiring NIV were enrolled.
Diaphragmatic thickening fraction, lung aeration assessed through ultrasound, comfort, and grade of sedation-agitation as well as vital signs, i.e., peripheral oxygen saturation, blood pressure, and breathing pattern were monitored during noninvasive ventilation in supine and after 1 hour following the switch to prone position.
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This study's enrollment of 24 is below the median of 261 across 3,136 observational studies indexed under COVID-19.
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Adult patient, admitted to intensive care unit for hypoxemic acute respiratory failure associated to COVID-19 requiring NIV, who were subjected to prone position for clinical purpouse.
Exclusion Criteria:
Patients were assisted in NIV in supine position that was switched in prone position for clinical purpouse
Diaphragmatic thickening fraction
The fraction of diaphragmatic thickness variations during respiratory cycle
Time frame: At baseline, in supine position
Diaphragmatic thickening fraction
The fraction of diaphragmatic thickness variations during respiratory cycle
Time frame: After 1 hour following prone position application
Lung aeration
Lung aeration assessed through sonography
Time frame: At baseline, in supine position
Peripheral oxygen saturation
Reflects the grade of peripheral oxygenation
Time frame: At baseline, in supine position
Lung aeration
Lung aeration assessed through sonography
Time frame: after 1 hour following prone position application
Peripheral oxygen saturation
Reflects the grade of peripheral oxygenation
Time frame: after 1 hour following prone position application
Plan to share: Undecided — single patients data on motivated request to principal investigator
This study is completed, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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Azienda Ospedaliera di Perugia