An interventional study of Coffee and Decaffeinated coffee in Healthy, sponsored by Temple University. Completed at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-08.
Sponsored by Temple University · Not applicable, Interventional, and Basic science
This study evaluates the effects of orally ingested, commercially available, coffee (3 mg/kg of caffeine) on the excitability of human spinal motoneurons of the lower leg.
Recently, it has been shown that human spinal motoneurons do not simply act as a binary control system. Instead, they are regulated by intrinsic properties that can elicit lingering effects on the descending motoneuron. Caffeine, one of the world's most popular over-the-counter supplements, can potentially augment these characteristics of motoneurons. Using decomposition software and non-invasive, high-density surface electromyography, it is possible to extract the characteristics of these motoneurons. This project will utilize a double-blind, inactive-placebo controlled, crossover design study to examine and quantify the effects of caffeine on motoneuron excitability.
Temple University is the lead sponsor of 219 studies on the registry; 30 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 7 (58%) have results posted.
Counted across the registry records on this site, refreshed daily.
● Between 18 and 70 years of age
Exclusion Criteria:
Single-dose, orally ingested, instant coffee.
Dietary Supplement: Coffee
Single-dose, orally ingested, instant decaffeinated coffee (equal weight to intervention dose).
Dietary Supplement: Decaffeinated coffee
Starbucks brand "Via" instant coffee. (Caffeine Content: 3 mg / kg)
Starbucks brand "Via" instant decaffeinated coffee. (Caffeine Content: 15 - 25 mg)
Motoneuron excitability (Delta-f)
Changes in motorneuron excitability, as quantified by Delta-F values. A paired motor unit technique will be utilized (Gorassini et al., 2002). (Typically, these values range from -5 to +10).
Time frame: Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention
Motor Unit Discharge Rate
Changes in motor unit discharge rate. This is a single value that ranges from, approximately, 0 to 30.
Time frame: Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention
Coherence
Changes in coherence values. Coherence provides a normalized value of the strength of correlation in the frequency domain. The magnitude of the correlation of the Fourier transforms of two spike trains is squared producing a value between 0 and 1, with 1 corresponding to a perfect linear prediction at a particular frequency (Rosenberg et al., 1989). This will be calculated using the composite spike train (Negro \& Farina, 2012) and, finally, z-transformed to allow for between-trial comparisons.
Time frame: Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention
Motor Unit Recruitment Threshold
Changes in motor unit recruitment threshold. As assessed by determining the amount of force (percentage of maximum volitional force output) needed to recruit an individual motor unit.
Time frame: Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention
Plan to share: No
This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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Temple University