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Active, not recruitingNCT04829994Updated Jul 6, 2026

Post-Market Clinical Follow-Up onTVT EXACT® Continence System

An observational study in Stress Urinary Incontinence, sponsored by Ethicon, Inc.. Active, not recruiting at 8 sites in 6 countries. Open to female participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2026-07-06.

Sponsored by Ethicon, Inc. · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
198
Ages
21 Years and older
Sex
Female
01

Study summary

The objective of this single arm, post market, clinical study is to evaluate the performance of Gynecare TVT EXACT® Continence System in women undergoing retropubic mid-urethral sling surgery for Stress Urinary Incontinence (SUI).

02

Conditions studied

  • Stress Urinary Incontinence

Keywords

  • GYNECARE TVT EXACT® Continence System
  • SUI
03

Who can participate

Ages eligible
21 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Female subjects ≥ 21 years of age with a diagnosis of SUI, resulting from utrethral hypermobility and/or intrinsic sphincter deficiency.

Inclusion criteria

Subjects who satisfy all of the following criteria will be considered eligible for enrollment in this study:

  1. Stress urinary incontinence symptoms
  2. Stress urinary incontinence confirmed by diagnostic evaluation of a cough stress test
  3. Female subjects ≥ 21 years of age requiring treatment of SUI
  4. Desired surgical correction of stress urinary incontinence using a synthetic pubo-urethral vaginal sling
  5. Planned surgery for primary stress incontinence without concomitant prolapse surgery
  6. Patient able and willing to participate in follow-up
  7. Subject or authorized representative has signed the approved informed consent

Exclusion criteria

Exclusion Criteria:

Subjects meeting any of the following criteria will be considered not eligible for enrollment in this study:

  1. Physical or psychological condition which would impair study participation or are unwilling or unable to participate in all required study visits and are unable to complete the questionnaires
  2. Any pre-operative or intra-operative findings identified by the surgeon that may preclude the use of study product
  3. History of previous synthetic, biologic or fascial pubo-urethral sling
  4. Pregnancy or plans for future pregnancy
  5. History of bleeding diathesis or current anti-coagulation therapy which cannot be suspended peri-operatively according to site's standard practice.
  6. Current genitourinary fistula or urethral diverticulum
  7. Reversible cause of incontinence (i.e. drug effect)
  8. Contraindication to surgery
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
198 participants (actual)
Patient registry
No

Interventions

  • DeviceIntervention

    There is no intervention, beyond necessary clinical care, in this study. The surgical procedures being performed within the study are identical to the surgical procedures subjects would receive as part of SOC.

05

What researchers measure

Primary outcomes

  1. Cough Stress Test (CST) Assessment Change

    Objective cure of Stress Urinary Incontinence (SUI) (treatment success) sproximately 5-10 years after surgery, defined as a negative CST

    Time frame: Post-surgery through study completion, approximately 5-10 yrs

Secondary outcomes

  1. Patient Global Impression of Improvement (PGI-I)

    Time frame: Post-surgery through study completion, approximately 10 yrs

  2. International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF)

    Time frame: Baseline and post-surgery through study completion, approximately 10 yrs

  3. Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12)

    Time frame: Baseline and post-surgery through study, approximately 10 yrs completion

  4. Wong-Baker FACES® Pain Rating Scale

    To assess pain on a scale from 0 (no pain) to 10 (worst pain) related to study device or procedure

    Time frame: Post-surgery through study completion, approximately 10 yrs

06

Study locations

8 sites
  • Duke University
    Durham, North Carolina 27707, United States
  • Institute for Female Pelvic Medicine
    North Wales, Pennsylvania 19454, United States
  • UPMC
    Pittsburgh, Pennsylvania 15213, United States
  • Ordensklinikum Linz
    Linz, Austria
  • Herlev Hospital
    Hillerød, Denmark
  • Hopital Jeanne de Flandres
    Lille, France
  • Universitatsklinikum Tubingen
    Tübingen, Germany
  • Karolinska Institute
    Stockholm, Sweden
07

References and documents

Individual participant data

Plan to share: Yes — Johnson \& Johnson Medical Device Companies have an agreement with the Yale Open Data Access (YODA) Project to serve as the independent review panel for evaluation of requests for clinical study reports and participant level data from investigators and physicians for scientific research that will advance medical knowledge and public health. Requests for access to the study data can be submitted through the YODA Project site at http://yoda.yale.edu.

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT04829994
Lead sponsor
Ethicon, Inc.
Responsible party
Sponsor
First posted
Apr 2, 2021
Start date
Jul 7, 2021
Primary completion
Sep 30, 2030 (estimated)
Completion
Sep 30, 2035 (estimated)
Last update
Jul 6, 2026

Study contacts

Martin Weisberg, MD
study director · Ethicon, Inc.

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

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