An observational study in Cerebral Amyloid Angiopathy and Subarachnoid Hemorrhage, sponsored by Centre Hospitalier Universitaire de Nīmes. Completed at 1 site in France. Open to participants aged 55 Years and older. Per ClinicalTrials.gov, last updated 2021-04-01.
Sponsored by Centre Hospitalier Universitaire de Nīmes · Observational
Transient focal neurological episode (TFNE) is the most frequent presenting symptom of convexity subarachnoid haemorrhage (cSAH) in elderly patients with non-traumatic cSAH with suspected, possible or probable cerebral amyloid angiopathy (CAA). The aim of our study was to analyse in detail clinical and MRI characteristics in these patients.
Methods: We performed a retrospective study analysing baseline, acute clinical symptom (TFNE and headache), and MRI characteristics (acute cSAH and chronic CAA features) of consecutive elderly (≥55 years) patients, recruited and registered in the stroke database, between june 2008 and october 2020 of two centres (Nîmes and Montpellier University Hospital, France), presenting with cSAH with suspected, possible, or probable CAA.
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This study's enrollment of 50 is below the median of 117 across 226 observational studies indexed under Subarachnoid Hemorrhage.
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consecutive elderly (≥55 years) patients, recruited and registered in the stroke database of two centres (Nîmes University Hospital and Montpellier University Hospital, France), presenting with cSAH with suspected, possible, or probable CAA.
The patients were classified as possible or probable CAA according to the modified Boston criteria. Since cortical superficial siderosis (CSS), incorporated in the modified Boston criteria, is probable a result of an earlier acute cSAH, we considered patients with acute cSAH in the absence of other typical CAA-related haemorragic features as patients with suspected CAA.
Exclusion Criteria:
Consecutive elderly (≥55 years) patients, recruited and registered in the stroke database of two centres (Nîmes University Hospital and Montpellier University Hospital, France), presenting with cSAH with suspected, possible, or probable CAA.
Other: usual care
according to recommendations
Description of MRI
Extent of acute cSAH (number of sulci, focal \[≤3 sulci\] or diffuse \[\>3 sulci\], surface)
Time frame: day of the diagnosis
Description of MRI
the multifocality of acute cSAH (as described for cortical superficial siderosis (CSS)), sulci involved by cSAH, CSS presence, CSS extent (focal, ≤3 sulci; diffuse \>3 sulci)
Time frame: day of the diagnosis
Description of MRI
cerebral microbleeds (CMB, \<10 mm) presence
Time frame: day of the diagnosis
Description of MRI
cerebral microbleeds number
Time frame: day of the diagnosis
Description of MRI
cerebral microbleeds categorisation (according to the Microbleed Anatomical Rating Scale),
Time frame: day of the diagnosis
Description of MRI
presence and number of chronic lobar intracerebral haemorrhage (ICH) (\>10 mm)
Time frame: day of the diagnosis
Description of MRI
Extent of white matter hyperintensities (periventricular Fazekas scale 0-3)
Time frame: day of the diagnosis
Clinical parameters
Transient focal neurological episode (TFNE) presence
Time frame: day of the diagnosis
Clinical parameters
number of TFNE preceding MRI
Time frame: day of the diagnosis
Clinical parameters
TFNE symptoms (sensory, motor, visual, speech; positive or negative symptoms
Time frame: day of the diagnosis
Clinical parameters
Presence and speed of spreading TFNE symptoms
Time frame: day of the diagnosis
Clinical parameters
Correlation of TFNE symptoms to cSAH localisation
Time frame: day of the diagnosis
Clinical parameters
headache (Yes/No)
Time frame: day of the diagnosis
Clinical parameters
antiepileptic drugs (AED) introduction and type of AED introduced
Time frame: day of the diagnosis
This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Nīmes