CClinicalTrials.gg
WithdrawnNCT04789551Updated Jun 2, 2026

T Cell Profiling in Patients With Multiple Sclerosis

An observational study in Multiple Sclerosis, sponsored by Boston Children's Hospital. Withdrawn at 1 site in United States. Open to participants aged 13 Years to 20 Years. Per ClinicalTrials.gov, last updated 2026-06-02.

Sponsored by Boston Children's Hospital · Observational

Why this study was withdrawn
Never began
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
0
Ages
13 Years to 20 Years
Sex
All
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Study summary

The goal of this research study is to to learn more about the body's immune response in patients with multiple sclerosis (MS). In MS, the body's immune cells mistakenly attack an important part of the nerves of the brain and spinal cord. The immune cells responsible for attacking the nerves in MS patients is primarily the T cells. A marker was recently discovered that might specifically identify these damaging T cells from all other T cells in the body. Understanding which T cells cause the damage in MS patients and understanding more about these specific T cells may help doctors better understand how MS occurs and could possibly prevent MS in the future.

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Conditions studied

  • Multiple Sclerosis

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In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

Browse Multiple Sclerosis studies →

Lead sponsor

Boston Children's Hospital is the lead sponsor of 598 studies on the registry; 151 are open to participants now.

Of its 31 completed or terminated interventional studies of FDA-regulated products, 18 (58%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
13 Years to 20 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with Multiple Sclerosis who present to Boston Children's Hospital will be enrolled. A group of healthy control patients who present for elective surgery at Boston Children's Hospital will also be enrolled.

Eligibility criteria

MS Group Inclusion criteria

-diagnosis of multiple sclerosis and present to the neurology clinic for a regular checkup or are admitted to the inpatient floor with acute symptoms.

Exclusion criteria

  • Have an active infection
  • Take T cell modulating drugs

Control Group Inclusion criteria -scheduled for elective surgery

  • without any immunological diseases. Exclusion criteria
  • Have an active infection.
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
0 participants (actual)
Patient registry
No

Groups and cohorts

  • Multiple Sclerosis Stable Conditions

    Multiple sclerosis patients presenting for a routine clinic visit.

    Other: Blood Sample

  • Multiple Sclerosis Acute Flare Up

    Multiple sclerosis patients admitted to the hospital with acute symptoms.

    Other: Blood Sample

  • Control patients

    Patients without any immunological diseases who present for elective surgery.

    Other: Blood Sample

Interventions

  • OtherBlood Sample

    a blood sample will be collected

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What researchers measure

Primary outcomes

  1. T cell populations

    compare T cell populations between patients with Multiple Sclerosis and healthy controls

    Time frame: up to one week

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Study locations

1 site
  • Boston Children's Hopsital
    Boston, Massachusetts 02115, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 2, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04789551
Lead sponsor
Boston Children's Hospital
Responsible party
Sponsor
First posted
Mar 9, 2021
Start date
Dec 1, 2025 (estimated)
Primary completion
Oct 1, 2026 (estimated)
Completion
Dec 1, 2026 (estimated)
Last update
Jun 2, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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