An interventional study of transcranial direct current stimulation in Epilepsy, sponsored by Assistance Publique Hopitaux De Marseille. Completed at 1 site in France. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2026-05-08.
Sponsored by Assistance Publique Hopitaux De Marseille · Not applicable, Interventional, and Treatment
This project aims to conduct a pilot study based on the targeting of the epileptogenic zone previously localized very precisely by stereoelectroencephalography (SEEG). SEEG is used as part of the pre-surgical assessment. It consists, thanks to the intracerebral implantation of electrodes in the brain of patients, to perform an intracerebral electrophysiological recording and thus to precisely explore the epileptogenic regions.
In order to study the neuromodulatory and therapeutic effects of tDCS on epileptic brains, non-invasive techniques for measuring electrophysiological brain activity such as magnetoencephalography (MEG) and high-resolution electroencephalography (HR EEG) will be used.
Finally, since epilepsy is considered to be a disorder of brain functional networks associated with disturbed brain connectivity, the effects of tDCS on cortical excitability by studying the variations in functional connectivity induced by stimulation will be studied.
1,805 studies on the registry are indexed under Epilepsy; 417 are open to participants now.
This study's enrollment of 17 is below the median of 50 across 1,206 interventional studies indexed under Epilepsy.
Browse Epilepsy studies →Assistance Publique Hopitaux De Marseille is the lead sponsor of 686 studies on the registry; 148 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patient will be treated for 3 cycles. A cycle is composed of 5 bi-sessions (one per day) of 20 minutes each.
Device: transcranial direct current stimulation
Patients will be treated using Starstim 8 device, a device allowing to perform transcranial direct current stimulation. The position of electrodes will be personalized based on the localization of the epileptogenic zone.
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 2
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 4
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 6
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 8
Depression
Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) - score to 6 to 24, higher values mean worse outcome
Time frame: Comparison between baseline and month 8
Anxiety disorders
Generalized Anxiety Disorder-7 (GAD-7) - score between 0 to 21, higher values mean worse outcome
Time frame: Comparison between baseline and month 8
Seizures evaluation
National Hospital Seizure Severity Scale (NHS3) - score 1 to 31, higher values mean worse outcome
Time frame: Comparison between baseline and month 8
Brain functional connectivity
National Hospital Seizure Severity Scale (NHS3) score 1 to 31, higher values mean worse outcome
Time frame: Comparison between day 1 and day 5 of each session
Plan to share: No
This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Assistance Publique Hopitaux De Marseille