An observational study in Thyroid Disorder and Corneal Opacity, sponsored by Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital. Completed at 1 site in Turkey. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-02-16.
Sponsored by Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Observational
In this cross-sectional comparative study, it is aimed to investigate the topographic measurements,aberrometrics and densitometrics values of corneas in hypothyroid and hyperthyroid patients compared to healthy individuals. A number of 20 hypothyroid patients (group I), 20 hyperthyroid patients (group II), and 20 age-matched healthy controls (group III) have been recruited. The Pentacam high resolution imaging system is used to determine corneal topographic measurements,aberrometry and densitometry.
Thyroid hormone diseases can cause different symptoms and signs in the body according to the hormone levels, particularly in the eyes. Corneal tissue can be affected by many biochemical and hormonal factors, and many ocular surface and systemic diseases can affect the cornea.Hyperthyroidism has been shown to cause symptoms such as conjunctival chemosis, proptosis, increased intraocular pressure, limitation to globe movements due to the restriction of extraocular muscles, increased orbital volume, increased risk of glaucoma with inflammation in the trabecular meshwork and exposure keratopathy, especially in Graves' disease. In the case of hypothyroidism, studies have shown fluid retention and edema in all body tissues, thereby resulting in increased thickness in the cornea, as well as a decrease in corneal hysteresis, which increases the risk of glaucoma. In this study, it is aimed to assess whether thyroid hormone changes affect those parameters by objectively measuring corneal changes via corneal topography, corneal densitometry and corneal aberrometry.
365 studies on the registry are indexed under Thyroid Diseases; 80 are open to participants now.
This study's enrollment of 60 is below the median of 198 across 158 observational studies indexed under Thyroid Diseases.
Browse Thyroid Diseases studies →Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital is the lead sponsor of 59 studies on the registry; 25 are open to participants now.
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20 patients diagnosed hypthyroidia ,20 patients diagnosed hyperthyroidia ,20 age matched healthy individuals
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Exclusion Criteria:
20 subjects diagnosed with hypothyroidism
20 subjects diagnosed with hyperthyroidism
20 age-matched healthy control subjects
corneal density in throid patients
corneal density values according to type of thyroid disorder
Time frame: up to 12 weeks
Ran from Jun 2020 to primary completion in Jan 2021, 6 months.
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This study is completed, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
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Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital