An interventional study of Endoscopic laser resection and Dilatation in Tracheal Stenosis, sponsored by Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec. Terminated at 4 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-06.
Sponsored by Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec · Not applicable, Interventional, and Treatment
Multicenter randomized controlled trial comparing endoscopic laser resection vs dilatation in benign tracheal stenosis.
An observational study suggests the superiority of endoscopic laser resection over dilatation in idiopathic tracheal stenosis but little litterature has been published on the subject. Hence we decided to design a prospective multicenter open label randomized controlled trial to compare the two interventions. Patients refered for endoscopic treatment of a simple benign tracheal stenosis will be randomized to endoscopic laser resection or dilatation. Randomisation will be stratified for center, type of stenosis (idiopathic vs other) and history of previous endoscopic treatment. Patients will be blinded to treatment but not physician. All patients will be treated with proton pump inhibitors.
37 studies on the registry are indexed under Tracheal Stenosis; 11 are open to participants now.
This study's enrollment of 108 is above the median of 22 across 22 interventional studies indexed under Tracheal Stenosis.
Browse Tracheal Stenosis studies →Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec is the lead sponsor of 23 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Using CO2, diode or similar wavelenght laser the stenotic tracheal segment will be vaporized allowing a less than 20% residual stenosis. Dilatation will not be performed after laser resection for residual stenosis.
Procedure: Endoscopic laser resection
Using a ballon or rigid bronchoscope the stenotic tracheal segment will be dilated with or without previous radial incision with electrocautery or laser.
Procedure: Dilatation
Laser resection
Dilatation
Relapse rate at 2 years of symptomatic tracheal stenosis (> 40%) requiring a new procedure
Time frame: Within 2 years
Relapse rate at 1 year of symptomatic tracheal stenosis (> 40%) requiring a new procedure
Time frame: 1 year
Time to first symptomatic relapse of tracheal stenosis
Time frame: 2 years
mMRC
Time frame: 2 years
VAS
Time frame: 2 years
Clinical COPD questionnaire
Time frame: 2 years
VHI-10
Time frame: 2 years
SF-12
Time frame: 2 years
Measurement of stenosis by cephalo-caudal length at endoscopic follow-up at 1 year
Time frame: Within 2 years
Rate of surgical resection following symptomatic recurrence
Time frame: 2 years
Rate and type of complications and adverse effects depending on the procedure
Time frame: 2 years
Relapse rate at 2 years of symptomatic tracheal stenosis (> 40%) requiring a new procedure in the idiopathic and non idiopathic subroup as well as in the first episode and recurrence subgroups
Time frame: 2 years
Plan to share: No
This study is terminated, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec