An observational study in Covid19, Corona Virus Infection and Vaccine Effectiveness, sponsored by Clalit Health Services. Completed at 6 sites in Israel. Open to participants aged 18 Years to 120 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-07-20.
Sponsored by Clalit Health Services · Observational
Although clinical trials for approved COVID-19 vaccines demonstrated efficacy of the vaccine in preventing symptomatic infection, many questions about vaccine effectiveness, such as the effectiveness of COVID-19 vaccine in preventing asymptomatic infection, a surrogate for transmission, and duration of protection, can only be evaluated in real-world trials. The objective of the study is to evaluate COVID-19 vaccine effectiveness (Pfizer vaccine, and, if available, Moderna vaccine) in preventing infection in healthcare personnel in Israel. HCP who are Clalit members and working in Soroka, Beilinson, Meir, Haemek, Kaplan and Schneider hospitals, 18 years or older, and eligible to get COVID-19 vaccine according to Ministry of Health guidelines, will be recruited, regardless of their intention to get the COVID-19 vaccine. A baseline serology sample and respiratory sample will be collected. Participants will be asked to provide a respiratory sample weekly for 3 months, and then monthly for the remainder of the study. Participants will also have blood drawn at 1 month, 3 months, 6 months, 9 months and 12 months. Respiratory samples will be tested for SARS-CoV-2 by RT-PCR; serology will be tested for SARS-CoV-2 antibodies. The study will last for 12 months. For each participant, data will be extracted from the Electronic Medical Record for the period of the study and retrospectively from 2010.
7,990 studies on the registry are indexed under COVID-19; 466 are open to participants now.
This study's enrollment of 1,567 is above the median of 268 across 3,208 observational studies indexed under COVID-19.
Browse COVID-19 studies →Clalit Health Services is the lead sponsor of 44 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Healthcare workers who work in 6 Clalit hospitals in Israel (Soroka, Kaplan, Meir, Beilinson, HaEmek, and Schneider)
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
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Employees at any of the participating hospitals will be excluded if they are:
participants who received the Covid-19 vaccine
Diagnostic Test: Serologic test · Diagnostic Test: Respiratory swabs
participants who didn't received the Covid-19 vaccine
Diagnostic Test: Serologic test · Diagnostic Test: Respiratory swabs
A blood test to check antibodies type and amount
PCR test to Covid-19
COVID-19 vaccine effectiveness (VE)
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers
Time frame: 18 months
Symptomatic SARS-CoV-2 infection in vaccinated vs. unvaccinated healthcare workers
Incidence of symptomatic SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers
Time frame: 18 months
asymptomatic SARS-CoV-2 infection in vaccinated vs. unvaccinated healthcare workers
Incidence of symptomatic SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers
Time frame: 18 months
Duration of effectiveness of the vaccine
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers over different periods of time
Time frame: 18 months
Vaccine Effectiveness by age
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers of different age groups
Time frame: 18 months
Vaccine Effectiveness by comorbidity
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers by various underly medical conditions
Time frame: 18 months
Vaccine effectiveness in persons previously infected with SARS-CoV-2 virus
Incidence of SARS-CoV-2 infections in previously infection healthcare workers vaccinated with COVID-19 vaccine compared to previously infection unvaccinated healthcare workers
Time frame: 18 months
VE by degree of exposure to COVID-19 patients
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers by degree of occupational exposure to COVID-019 patients
Time frame: 18 months
VE by different SARS-CoV-2 variants
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with COVID-19 vaccine compared to unvaccinated healthcare workers for different variant strains of SARS-CoV-2
Time frame: 18 months
Vaccine effectiveness of one dose compared to two doses
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with two doses of COVID-19 vaccine compared to healthcare workers vaccinated with two doses of COVID-19 vaccine
Time frame: 18 months
Compartive vaccine Effectiveness of different vaccine brands
Incidence of SARS-CoV-2 infections in healthcare workers vaccinated with different brands of COVID-19 vaccine
Time frame: 18 months
Plan to share: Undecided
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This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Clalit Health Services