An interventional study of Transcranial magnetic stimulation and Sham transcranial magnetic stimulation in Parkinson Disease, sponsored by Luzerner Kantonsspital. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-09-06.
Sponsored by Luzerner Kantonsspital · Not applicable, Interventional, and Treatment
We investigate the effectiveness of a combined repetitive transcranial magnetic stimulation (rTMS) - video game-based training (VBT) dexterity intervention in Parkinson's diseases. The short and long-term benefits of this training program will be evaluated. For these purposes, a blinded sham controlled randomized controlled trial will be performed.
Patients with Parkinson's disease (PD) often exhibit dexterous difficulties during the performance of activities of daily living (ADL) such as tying shoe laces, hand-writing, using remote controls, smartphone or tablet. These difficulties further add to the burden of the disease, leading to reduced quality of life (QoL). A relatively new, but rapidly growing aspect of training in PD neurorehabilitation is exergaming. To enhance training effects a combination of repetitive transcranial magnetic stimulation (rTMS) with exergaming will be tested.
4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.
This study's enrollment of 30 is below the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Luzerner Kantonsspital is the lead sponsor of 60 studies on the registry; 23 are open to participants now.
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Exclusion Criteria:
The PD patients randomized in the experimental group will receive VBT each time preceded by a real rTMS stimulation.
Other: Transcranial magnetic stimulation
The PD patients randomized in the control group will receive VBT each time preceded by a sham TMS.
Other: Sham transcranial magnetic stimulation
Non-invasive brain stimulation
Non-invasive brain stimulation
DextQ-24
standardized patient self-rated outcome measure (PROM) for evaluating dexterity related ADL in PD
Time frame: 3 weeks
Nine Hole Peg test (9-HPT)
The 9-HPT is a standardized, well established, and reliable measure of hand dexterity in patients with PD.
Time frame: 3 weeks
Coin rotation task (CRT)
The CRT measures fine coordinated finger movements and is a suitable and valid dexterity test in patients with PD.
Time frame: 3 weeks
Plan to share: No
This study is completed, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.
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Luzerner Kantonsspital