An observational study in LTBI, BCG Vaccination Reaction and TB, sponsored by Thomayer University Hospital. Status unknown at 2 sites in Czechia. Open to participants aged 4 Years to 70 Years. Per ClinicalTrials.gov, last updated 2020-12-17.
Sponsored by Thomayer University Hospital · Observational
TB-reactive immune cells will be tested in a multiparametric flow cytometry to distinguish an immune response for antigens of Mycobacterium spp. in TB disease/latent infection or a reaction after BCG vaccine.
The goal of this project is the verification of current cytometric panel of detection antibodies in a wider panel of stimulative immunodominant antigens for CD4+ and CD8+ T cells in combination with adjuvants 2 in a in vitro activating test.
1,417 studies on the registry are indexed under Tuberculosis; 208 are open to participants now.
This study's planned enrollment of 120 is below the median of 250 across 421 observational studies indexed under Tuberculosis.
Browse Tuberculosis studies →Thomayer University Hospital is the lead sponsor of 5 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Study of the broad spectrum of population with the history of having an active TB infection or close contact with bacteriologically approved pulmonary TB
Inclusion Criteria: active TB, contact with TB infection in previous 3 months before the study
-
Exclusion Criteria:
After a close contact with bacteriologically confirmed TB suspicion for LTBI with an evidence of previous BCG vaccination status TB confirmed with TST (TST ≥ 5 mm or BCG unvaccinated or TST ≥ 15 mm for BCG vaccinated) 20 children and adolescents 20 adults
Diagnostic Test: Blood draw
Active TB group with positive microbial culture and pathological chest radiography or chest CT 20 children and adolescents 20 adults
Diagnostic Test: Blood draw
After a close contact with bacteriologically confirmed TB no evidence of TB in TST or IGRA test for 3 months 20 children and adolescents 20 adults
Diagnostic Test: Blood draw
Blood draw and the analysis of blood in laboratory
Peer-review publication of results of our study
Time frame: 2 years
Creation of new diagnostic tool and his comparision with existing IGRA test (QTF-GP and TST)
Time frame: 2 years
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Thomayer University Hospital