ClinicalTrials.gg
Active, not recruitingNCT04668885Updated Jun 12, 2026

CPX-351 as a Novel Approach for the Treatment of Older Patients With AML and MDS

A Phase 2 interventional study of CPX-351 in Refractory Acute Myeloid Leukemia, Relapsed Acute Myelomonocytic Leukemia and Myelodysplastic Syndromes, sponsored by Case Comprehensive Cancer Center. Active, not recruiting at 1 site in United States. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2026-06-12.

Sponsored by Case Comprehensive Cancer Center · Phase 2, Interventional, and Treatment

Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →

Phase
Phase 2
Study type
Interventional
Enrollment
13
Allocation
Non-randomized
Ages
60 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 53 studies testing CPX-351 in Leukemia, Myeloid, Acute — 15 open to participants now, 23 under way, 4 of them phase 3. CPX-351 · Leukemia, Myeloid, Acute.

Enrollment
42nd of 53
13 · median 30
Started
2021
with 4 others
Phase 2
25 of 53
6 open now
Primary completion
2026-01
later than 4 of 22 live
Registered
37th of 53
by date

Among the 53 studies testing CPX-351 in Leukemia, Myeloid, Acute, this one is the 42nd largest by enrollment, is one of 5 that started in 2021, is one of 25 in phase 2, reaches primary completion later than 4 of the 22 other live ones, and was the 37th registered.

Leukemia, Myeloid, Acute

3,668 studies on the registry are indexed under Leukemia, Myeloid, Acute; 816 are open to participants now.

Browse Leukemia, Myeloid, Acute studies →

Open to participants now

15 of the 53 studies testing CPX-351 in Leukemia, Myeloid, Acute are open now, in 5 countries. Recruiting first, the newest first:

10 more — sign in →

By country, each count listing its studies:

All 15 open studies →

About CPX-351

No approval found in the FDA or EMA files read. How studies give it is on its page →

Who these studies take

Of the 625 Leukemia, Myeloid, Acute studies recruiting now, 363 (58%) set no upper age limit and 222 (36%) stop at 75 or younger; 145 take children under 18; 29 take healthy volunteers.

This study: 60 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 53 studies testing CPX-351 in Leukemia, Myeloid, Acute, or all of them as a file.
02

Study summary

The purpose of this study is to evaluate how effective lower doses of CPX-351 are in older participants with relapsed/refractory acute myeloid leukemia (AML) who are not eligible to receive intensive chemotherapy and in participants with myelodysplastic syndromes (MDS) after Hypomethylating Agents (HMA) failure.

Read the detailed description

Currently, elderly patients with AML and high risk MDS, who are ineligible to receive induction chemotherapy and fail HMA +/- combination, have very poor outcomes and there is no FDA-approved therapy outside of some targeted therapies which can only be applied to a small patient population. CPX-351 is an investigational (experimental) drug that works by combining two anti-cancer drugs cytarabine and daunorubicin. CPX-351 is experimental because it is only FDA approved for the treatment of adults with two types of AML: newly diagnosed therapy-related AML or AML with myelodysplasia-related changes.

This is an open label clinical trial of lower doses of CPX-351 in relapsed/primary refractory older AML and MDS patients ineligible to receive intensive chemotherapy. The first arm is for particpants with primary refractory/relapsed AML and the second arm is for higher risk MDS participants after HMA failure.

03

Conditions studied

  • Refractory Acute Myeloid Leukemia
  • Relapsed Acute Myelomonocytic Leukemia
  • Myelodysplastic Syndromes
04

Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Primary or relapsed AML (defined by 2016 World Health Organization [WHO] criteria) patients who are not suitable for or not willing to receive intensive chemotherapy as evaluated by the treating physician. Primary refractory disease is defined as:

    • Failure to achieve a CR, CRi, or mLFS (defined as \<5% Bone Marrow (BM) blasts) after receiving 1 or 2 cycles of remission induction chemotherapy.
    • Failure to achieve a CR, CRi, or MLFS (defined as \<5% BM blasts) after receiving 4 cycles of non-intensive chemotherapy or whose disease progressed at any time point during the treatment.
  • Participants with MDS (according to 2016 WHO criteria) who did not respond to treatment with azacitidine, decitabine, or combination of HMA with another drug or lost their response to initial therapy with HMA.
  • (ECOG) performance status \<=2
  • Adequate hepatic (serum total \< 1.5 x , Serum glutamic pyruvic transaminase () and/or serum glutamate oxaloacetate transaminase (SGOT) \<2.5 x ULN) and renal function (creatinine \< 1.5mg/dL).
  • Participants must be willing and able to review, understand, and provide written consent before starting therapy.

Exclusion criteria

Exclusion Criteria:

  • Active signs or symptoms of central nervous system (CNS) involvement by (lumbar puncture [LP] not required).
  • Prior 7+3 remission induction chemotherapy for MDS or AML
  • More than 2 lines of prior non-intensive therapy.
  • (NYHA) class III or IV heart disease, active ischemia or any other uncontrolled cardiac condition such as angina pectoris, cardiac arrhythmia on rhythm control strategy or on pacemaker, uncontrolled hypertension (blood pressure > 160 systolic and > 110 diastolic not responsive to antihypertensive medication)
  • Acute myocardial infarction in the previous 12 weeks (from the start of treatment).
  • Any serious medical condition, laboratory abnormality, or psychiatric illness that, in the view of the treating physician, would place the participant at an unacceptable risk if he or she were to participate in the study or would prevent that person from giving .
  • Any active malignancy (unrelated, non-hematological malignancy) diagnosed within the past 6 months of starting the study drug (other than curatively treated carcinoma-in-situ of the cervix or non-melanoma skin cancer).
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to CPX-351.
  • Subjects with uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
  • Known history of or active or C.
  • No major surgery within 2 weeks prior to study enrollment.
  • Pregnant or breast feeding
  • Male and female participants who are fertile who do not agree to use an effective barrier methods of (i.e. abstinence) to avoid pregnancy while receiving study treatment and for 30 days after last dose of study treatment. Non-childbearing is defined as > 1 year or surgically sterilized.
  • Acute promyelocytic leukemia (APL)
Terms in these criteria, in plain language(13)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Relapsed and refractory

Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.

ECOG performance status

A scale of how much an illness limits everyday activity. For people being assessed to join a study, scores run from 0 (fully active) to 4; lower is more active.

0
Fully active, no restrictions.
1
Limited in strenuous activity, but walking and able to do light work, such as housework or office work.
2
Walking and able to look after yourself, but unable to work; up and about more than half of waking hours.
3
Able to look after yourself only in part; in bed or a chair more than half of waking hours.
4
Unable to look after yourself at all; in bed or a chair all day.

Studies most often ask for 0–1 or 0–2. Your doctor gives the score; the WHO scale uses the same steps. The full scale also has 5, which records death.

Bilirubin

A yellow substance made when red blood cells are broken down, which the liver clears. A high level can mean a problem with the liver or the bile ducts.

Criteria often allow more for people with Gilbert’s syndrome, a harmless inherited condition that raises bilirubin.

ULN (upper limit of normal)

The top of the normal range for a blood test, as set by the laboratory that runs it. Each lab prints its own range next to your result.

“≤ 2.5 × ULN” means the result can be up to two and a half times that top value.

ALT and AST (liver enzymes)

Two enzymes measured in a routine blood test of the liver. Higher levels can mean the liver is under strain or damaged. SGPT and SGOT are older names for ALT and AST.

Criteria usually give a limit as a multiple of the upper limit of normal (ULN), often higher when cancer has spread to the liver.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

NYHA class (heart failure)

The New York Heart Association’s four classes of how much heart failure limits physical activity.

I
No limits: ordinary activity causes no undue tiredness or breathlessness.
II
Slight limits: comfortable at rest, ordinary activity causes symptoms.
III
Marked limits: comfortable at rest, less than ordinary activity causes symptoms.
IV
Symptoms even at rest; any activity makes them worse.

Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.

Clinically significant

Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

Hepatitis B tests

Hepatitis B is a virus that infects the liver. These are separate tests: HBsAg positive usually means a current infection (a recent vaccination can briefly cause it too); total anti-HBc (HBcAb) positive means an infection now or in the past; HBV DNA measures how much virus is in the blood.

Some studies accept a past infection if HBV DNA is undetectable, sometimes with antiviral medicine during the study. Check what this study allows.

Contraception

Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.

Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.

Postmenopausal

Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).

05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
13 participants (actual)

Study arms

  • Experimental
    Primary refractory/relapsed AML

    Lower dose CPX-351 in participants with primary refractory/relapsed AML. Participants will receive an induction and maintenance phase of CPX-351

    Drug: CPX-351

  • Experimental
    MDS after HMA failure

    Lower dose CPX-351 in participants with MDS after HMA failure. Participants will receive an induction and maintenance phase of CPX-351

    Drug: CPX-351

Interventions

  • Induction phase: CPX-351 15 mg/m\^2 on days 1 and 3 of each 28-day cycle for up to a total of 6 cycles in the absence of unacceptable toxicity Maintenance phase: CPX-351 7.5 mg/m\^2 on days 1 and 3 for two cycles alternating with 15 mg/m\^2 for one cycle. Participants may receive up to 12 cycles of maintenance phase in the absence of unacceptable toxicity.

06

What researchers measure

Primary outcomes

  1. Overall response rate (ORR) per 2003 International Working Group (IWG) criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 6 months

  2. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 1 year

  3. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 1.5 years

  4. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 2 years

  5. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 2.5 years

  6. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 3 years

  7. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 3.5 years

  8. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 4 years

  9. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 4.5 years

  10. Overall response rate (ORR) per 2003 IWG criteria

    ORR = complete response (CR) + CR with incomplete blood count recovery (CRi) + partial remission (PR) as defined by 2003 IWG criteria for AML patients, and ORR = CR + PR + hematologic improvement (HI) and as defined per 2006 IWG criteria for MDS patients

    Time frame: At 5 years

Secondary outcomes

  1. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 6 months

  2. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 1 year

  3. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 1.5 years

  4. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 2 years

  5. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 2.5 years

  6. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 3 years

  7. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 3.5 years

  8. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 4 years

  9. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 4.5 years

  10. Time to response (TTR)

    TTR is measured from start of treatment to the date of achieving a response. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 5 years

  11. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 6 months

  12. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 1 year

  13. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 1.5 years

  14. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 2 years

  15. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 2.5 years

  16. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 3 years

  17. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 3.5 years

  18. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 4 years

  19. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 4.5 years

  20. Duration of response (DOR)

    DOR measured from the time of achieving a response to time of disease progression. Wilcoxon rank test will be used for comparison of continuous variables.

    Time frame: At 5 years

  21. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 6 months

  22. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 1 year

  23. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 1.5 years

  24. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 2 years

  25. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 2.5 years

  26. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 3 years

  27. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 3.5 years

  28. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 4 years

  29. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 4.5 years

  30. Event-free survival (EFS)

    EFS measured from date of first dose to the date of treatment failure, relapse, or death from any cause. Wilcoxon rank test will be used for comparison of continuous variables

    Time frame: At 5 years

  31. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 6 months

  32. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 1 year

  33. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 1.5 years

  34. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 2 years

  35. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 2.5 years

  36. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 3 years

  37. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 3.5 years

  38. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 4 years

  39. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 4.5 years

  40. Overall Survival (OS)

    OS measured from start of treatment to death or last follow up. OS function will be estimated using the Kaplan-Meier method

    Time frame: At 5 years

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: No — There are no plans to share individual patient data in order to protect the confidentiality of the participants who enroll on this study

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jan 2021 to primary completion in Jan 2026, 60 months.

Of 386 non-industry phase 2 interventional studies under Leukemia, Myeloid, Acute, half reached primary completion within 67 months of starting (the median), counting those still running; a quarter within 40 and three quarters within 108. This study's 60 months is below that.

Counting every sponsor, half of 443 studies reached it within 60 months; a quarter within 38 and three quarters within 104.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 9, 2020
First posted
Dec 16, 2020
StartActual
Jan 14, 2021
Primary completionActual
Jan 19, 2026
CompletionEst.
Jan 19, 2027
Last update
Jun 12, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 12, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04668885
Responsible party
Sponsor
First posted
Dec 16, 2020
Start date
Jan 14, 2021
Primary completion
Jan 19, 2026
Completion
Jan 19, 2027 (estimated)
Last update
Jun 12, 2026

Study contacts

Sudipto Mukherjee, MD, PhD
principal investigator · Cleveland Clinic, Case Comprehensive Cancer Center

Oversight

Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Studies of the drug tested here: CPX-351

Start the discussion