An observational study in Tonsillitis, Tonsillar Hypertrophy and Immune System Diseases, sponsored by Selcuk University. Completed at 1 site in Turkey. Open to participants aged 2 Years to 16 Years. Per ClinicalTrials.gov, last updated 2020-12-04.
Sponsored by Selcuk University · Observational
Tonsillar tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of the cells. The purpose of the study was to explore the correlation among ER stress and tonsillar tissue disorders and to explain the structure of diseases related to the immune system.
A prospective study was conducted on 46 children aged who underwent tonsillectomy for chronic tonsillitis or tonsil hypertrophy. Tonsil tissues were evaluated in terms of ER stress markers and apoptosis markers by Real-time PCR and Western blot methods.
103 studies on the registry are indexed under Tonsillitis; 12 are open to participants now.
This study's enrollment of 46 is below the median of 100 across 15 observational studies indexed under Tonsillitis.
Browse Tonsillitis studies →Selcuk University is the lead sponsor of 258 studies on the registry; 67 are open to participants now.
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Patients who underwent tonsillectomy surgery aged between 2 and 16 years and who were clinically diagnosed with chronic tonsillitis and tonsil hypertrophy by the ENT clinician.
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Exclusion Criteria:
Patients with tonsil sizes grade 1 and 2, and tonsillectomy indications included frequently recurrent tonsillary infection, sore throat, and malodorous mouth problems were accepted as the chronic tonsillitis group.
Procedure: Tonsillectomy surgery
Patients with tonsil size grades 3 and 4 and tonsillectomy indications included obstructive symptoms such as snoring, open mouth breathing, difficulty in breathing, and swallowing problems were accepted as the tonsillar hypertrophy group.
Procedure: Tonsillectomy surgery
The tonsillectomy procedure was performed under general anesthesia using the classical dissection method. Extracted tonsil tissue samples were sent to the medical genetics department in tubes to investigate the ER stress and apoptosis.
Relationship of Endoplasmic Reticulum stress and apoptosis with chronic tonsillitis and tonsillar hypertrophy
Our primary outcome was to evaluate providing that Endoplasmic Reticulum stress and apoptosis reaction performing in chronic tonsillitis and tonsillar hypertropy, which is related with the immune system of children. GRP78, CHOP, ATF6, ATF4 proteins will be investigated in tonsillar tissues to evaluate ER stress index, and bax, bcl2 proteins will be investigated to evaluate apoptosis.
Time frame: 2018-2020
Plan to share: Undecided — We will share the study protocol after our article has been accepted for publication in a journal.
Ran from Nov 2018 to primary completion in Jun 2019, 7 months.
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This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
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