An observational study in Achalasia, sponsored by Methodist Health System. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-10.
Sponsored by Methodist Health System · Observational
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Among 52 studies in Esophageal Achalasia with a site in United States — 18 open to participants now, 18 under way, 2 of them phase 3. Esophageal Achalasia · United States.
Among the 52 studies in Esophageal Achalasia with a site in United States, this one is the 7th largest by planned enrollment of the 19 observational ones that give a count, is one of 2 that started in 2019, is one of 19 observational ones, reaches primary completion later than 4 of the 17 other live ones, and was the 34th registered.
143 studies on the registry are indexed under Esophageal Achalasia; 44 are open to participants now.
Browse Esophageal Achalasia studies →18 of the 52 studies in Esophageal Achalasia with a site in United States are open now. Recruiting first, the newest first:
Northwestern University · Sites in United States
Ages 18+
Johns Hopkins University · Sites in United States
Ages 5–21
Northwestern University · Sites in United States
Ages 18+
Baylor College of Medicine · Sites in United States
Ages 18+
The Cleveland Clinic · Sites in United States
Ages 18+
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 31 Esophageal Achalasia studies recruiting now, 20 (65%) set no upper age limit and 5 (16%) stop at 75 or younger; 3 take children under 18; 1 takes healthy volunteers.
This study: 18 Years and older · all sexes.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
52 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 4 · Phase 3 2 · Phase 4 4
First in 1999; this study’s year is marked. 2 started in 2019.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 200 is above the median of 111 across 41 observational studies indexed under Esophageal Achalasia.
Median enrollment 42 across the 33 interventional studies, 200 across the 19 observational. Of the 26 that completed or were terminated, 1 (4%) have results posted.
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1 of 52 have an industry lead sponsor. The 10 most frequent:
Methodist Health System is the lead sponsor of 170 studies on the registry; 50 are open to participants now.
Methodist Health System has 1 study filed under Esophageal Achalasia — fewer than ten, so there is no comparison to draw.
4 of the studies in Esophageal Achalasia with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04640753Methodist Health SystemPeroral Endoscopic Myotomy for the Treatment of Achalasia | 2027-02-05 |
| NCT07780981Johns Hopkins UniversityImpact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions | 2027-07-01 |
| NCT07496840Baylor College of MedicineClinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM) | 2027-07-30 |
| NCT05550194Vanderbilt University Medical CenterVZV in the Enteric Nervous System: Pathogenesis and Consequences | 2027-08 |
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Among the 52 studies in Esophageal Achalasia with a site in United States, from their registry updates:
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There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 \& a prospective chart review will be performed for patients who will undergo endoscopic procedures and POEM from 02/2019 - 06/2021
Subjects will undergo no additional tests and procedures as part of this study. All data will be collected from patient's electronic health records (EHR) of the hospital In addition; a prospective chart review will be performed for patients who will undergo endoscopic procedures and POEM from 02/2019 - 06/2021. All the subjects enrolled in prospective chart review will be first consented for their study participation. Subjects will undergo a clinically indicated endoscopic procedure and POEM and subsequent follow-up clinical visits as part of their standard medical care. All procedures, barring research activities such as consenting and data collection from Electronic Health Records, will be either clinically indicated and/or standard of care.
"Disclaimer: Any cost associated with the procedures stated herein will be billed directly to you or to your insurance (as applicable)."
There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019. In addition; a prospective chart review will be performed for patients who will undergo endoscopic procedures and POEM from 02/2019 - 06/2021.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
POEM procedure will have a high technical feasibility, with effective clinical resolution of symptoms both in the short and long term.
Decrease or no symptoms of chest pain
To continue and review our treatment outcomes, patient safety in cases with achalasia, we follow up after the procedure up to 180 days. Follow-up period varies from patient to patient.
Time frame: upto 180 days
Plan to share: Undecided
No publications or documents are linked to this record.
Started Feb 2019 (actual). Primary completion is estimated for Feb 2027, 95 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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