An interventional study of Venous blood collection in Oxygen Deficiency, sponsored by Medical University Innsbruck. Completed at 1 site in Austria. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-09-08.
Sponsored by Medical University Innsbruck · Not applicable, Interventional, and Basic science
The presented study is an experimental in-vitro study without intervention in-vivo. The effects of nitric oxide and prostacyclins, 5-hydroxymethylfurfural and alpha-ketoglutarate, volatile anaesthetics on haemoglobin oxygen (HbO2) affinity will be investigated in-vitro. Venous blood samples of 20 healthy young volunteers (10 female, 10 male) will be collected twice in the period of one week. Informed consent will be given. Every blood collection will be accompanied by a venous blood gas analysis. The blood samples will be transferred to the laboratory for in-vitro recording of the complete oxygen dissociation curve (ODC). A newly developed in-vitro method will be used. On the first study day the blood samples will be exposed to three different concentrations of nitric oxide during the measurement, followed by two different vapourized prostacyclins. In addition, different concentrations of 5-hydroxymethylfurfural and alpha-ketoglutarate will be given to the blood samples for ODC recording. On the second study day the dose dependent effects of three different volatile anaesthetics will be investigated by exposing the blood samples to these drug while the measurements. Following these ODC recordings, aliquots of the blood samples will be frozen and investigated for storage related changes in HbO2 affinity.
1,231 studies on the registry are indexed under Hypoxia; 241 are open to participants now.
This study's enrollment of 22 is below the median of 45 across 853 interventional studies indexed under Hypoxia.
Browse Hypoxia studies →Medical University Innsbruck is the lead sponsor of 182 studies on the registry; 49 are open to participants now.
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Exclusion Criteria:
The blood samples of all participants will be treated equally according to the study protocol. No intervention in-vivo.
Other: Venous blood collection
Two venous blood collections in within one week. No drug-related intervention in-vivo.
P50
Partial pressure of oxygen, at which 50% of haemoglobin is saturated with oxygen.
Time frame: One day
Hill coefficient
Parameter describing the cooperativity of oxygen ligand binding to haemoglobin.
Time frame: One day
Plan to share: No
This study is completed, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.
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Medical University Innsbruck