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CompletedNCT04608526Updated Oct 29, 2020

Relationship Between Tooth Decay and Trabecular Bone

An observational study in Dental Caries in Children, Pediatric Patients and Radiology, sponsored by Recep Tayyip Erdogan University Training and Research Hospital. Completed at 1 site in Turkey. Open to participants aged 8 Years to 13 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-10-29.

Sponsored by Recep Tayyip Erdogan University Training and Research Hospital · Observational

Study type
Observational
Model
Case-crossover
Time perspective
Retrospective
Enrollment
120
Ages
8 Years to 13 Years
Sex
All
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Study summary

Chewing, a movement that matures with experiences, has effects on the growth and development of the stomatognathic system. Tooth decay, which is known to have effects on chewing, can affect the jaw bone due to its indirect effect on the mechanical forces transmitted to the jaw bone. This study was aimed to evaluate the relationship between dental caries and jaw bone trabeculation during the growth and development processes in children by fractal dimension analysis method. 40 patients with deep-dentin caries / apical rarefying osteitis on the right or left side, 40 patients with deep-dentin caries / apical rarefying osteitis on either the right and left sides and 40 patients without deep-dentin caries / apical rarefying osteitis between 8-13 ages were randomly selected. Digital panoramic images of the selected patients were analyzed with fractal dimension analysis.

02

Conditions studied

  • Dental Caries in Children
  • Pediatric Patients
  • Radiology

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Keywords

  • Disturbances in dental development
  • fractal analysis
  • pediatric patients
  • radiology
03

In context

Dental Caries

1,109 studies on the registry are indexed under Dental Caries; 197 are open to participants now.

This study's enrollment of 120 is below the median of 180 across 177 observational studies indexed under Dental Caries.

Browse Dental Caries studies →

Lead sponsor

Recep Tayyip Erdogan University Training and Research Hospital is the lead sponsor of 85 studies on the registry; 19 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
8 Years to 13 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

  • systemically healthy,
  • 8-13 years-old,
  • applied to the Clinic between January 2018 and April 2020 patients

Inclusion criteria

  • Panoramic radiographs of systemically healthy 8-13 years-old patients,
  • Who applied to the Clinic between January 2018 and April 2020 were retrospectively scanned.
  • Patients with 1st molars whose root development was completed and the 2nd molars not erupted yet were included.

Exclusion criteria

Exclusion Criteria:

  • Patients with temporomandibular joint disorders, any systemic disease, exposed to trauma in the area to be measured, received orthodontic treatment for the last 2 years or had an ongoing orthodontic treatment, unilateral / bilateral cross-bite and had parafunctional habits in their anamnesis were excluded.
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Study design

Observational model
Case-crossover
Time perspective
Retrospective
Enrollment
120 participants (actual)
Patient registry
No

Groups and cohorts

  • Group 1

    Patients without deep dentin caries / apical rarefying osteitis

    Diagnostic Test: Fractal analysis

  • Group 2

    Patients with deep dentin caries / apical rarefying osteitis on the right or left sides

    Diagnostic Test: Fractal analysis

  • Group 3

    Patients with deep dentin caries / apical rarefying osteitis on either the right and left side

    Diagnostic Test: Fractal analysis

Interventions

  • Diagnostic testFractal analysis

    Fractal dimension (FD) analysis, which can be measured in panoramic radiographs, is a technique that can be used to measure mandibular trabecular architecture and to determine early periodontal changes in alveolar bone. Fractal analysis method, which has become more and more popular in recent years; has features such as being easily accessible, not being affected by variables such as projection geometry and radiological density and providing objective data about trabecular structures. It can be measured in the patients' existing panoramic images and does not require extra imaging and material.

06

What researchers measure

Primary outcomes

  1. The effects of dental caries on the jawbone in children aged between 8-13 years

    Digital panoramic radiographs of the patients included in the study were recorded in high resolution TIF (tagged image file) format to ensure standardization of the images and adjusted to 2836 x 1500 pixels. ImageJ version 1.53a, and bundled with 64-bit Java for Windows (National Institutes of Health, Bethesda) were used for fractal analysis of the images. Fractal analysis on digital panoramic radiographs transferred to ImageJ (National Institutes of Health, Bethesda) program, 3 ROI (region of interest) areas of 15x15 pixels were determined for each patient with condyle, antegonial notch in the right and left hemimandible and in the center of the ramus.The number of frames containing the trabecular structure and the total number of frames were calculated for different dimensions. The values were transferred to the logarithmic scale and the slope of the curve fitting the points on the graph gave the result of the fractal measurement.

    Time frame: for two months from the beginning of the study

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Study locations

1 site
  • Sema Aydinoğlu
    Rize, Turkey
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 29, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04608526
Lead sponsor
Recep Tayyip Erdogan University Training and Research Hospital
Responsible party
Sema Aydınoglu (assistant professor, Recep Tayyip Erdogan University Training and Research Hospital) — Principal investigator
First posted
Oct 29, 2020
Start date
Jun 1, 2020
Primary completion
Sep 1, 2020
Completion
Oct 19, 2020
Last update
Oct 29, 2020

Study contacts

SEMA AYDINOĞLU
study director · Recep Tayyip Erdogan University Training and Research Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.

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