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CompletedNCT04589481HALIDROPUpdated Jun 2, 2021

Effectiveness of Different Candies Against Bad Breath

An interventional study of Intake of 3 different candies against bad breath in Bad Breath, sponsored by University Hospital, Basel, Switzerland. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-06-02.

Sponsored by University Hospital, Basel, Switzerland · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
35
Allocation
Not applicable
Ages
18 Years to 40 Years
Sex
All
01

Study summary

This study is to analyze whether the candies can relieve or eliminate bad breath, both subjectively and objectively.

Read the detailed description

This study is to systematically examine an existing candy, which is easily available and is intended to relieve or eliminate bad breath. The main aim of the study is to determine the effectiveness of the candies on the subjective perception of bad breath. The secondary outcome of the study is to investigate whether there is actually a decrease in volatile sulphur compounds (VSC) in the exhaled air and also a decrease in bad breath during organoleptic measurement.

The purpose of the study is to investigate whether the different candies can relieve or eliminate bad breath, both subjectively and objectively.

02

Conditions studied

  • Bad Breath

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Keywords

  • halitosis
  • volatile sulphur compounds
03

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Non- smoker
  • No general medical illness or medication

Exclusion criteria

Exclusion Criteria:

  • Allergies/intolerances to ingredients of the products used
  • Chronic diseases
  • Smoker
  • Pregnancy
04

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
35 participants (actual)

Study arms

  • Experimental
    candy intake

    Other: Intake of 3 different candies against bad breath

Interventions

  • OtherIntake of 3 different candies against bad breath

    Intake of 3 different candies against bad breath on three different days (2-days interval each) after artificially creating a temporary bad breath (by eating of chips and cheese); analysis of breathing during intake of candy both subjectively and objectively

05

What researchers measure

Primary outcomes

  1. Organoleptic analysis of breathing air sample

    Assessment of the patient's bad breath on the basis of the subjective assessment of an investigator (scale of 0 to 5 (0, no odor; 1, questionable odor; 2, slight malodor; 3, moderate malodor; 4, strong malodor; 5, severe malodor))

    Time frame: max 60 minutes at 3 different days

  2. Measurement of volatile sulphur compounds (VSC) in ppb (parts per billion).

    Assessment of the patient's bad breath on the basis of the objective assessment by a sulfide monitor (HaliSens® AI Analytical Innovations GmbH, Moosbach, Germany)

    Time frame: max 60 minutes at 3 different days

06

Study locations

1 site
  • Universitäres Zentrum für Zahnmedizin UZB
    Basel, 4058, Switzerland
07

Registry details

Key details

Study ID
NCT04589481
Lead sponsor
University Hospital, Basel, Switzerland
Collaborators
Ricola Group AG Schweiz
Responsible party
Sponsor
First posted
Oct 19, 2020
Start date
Feb 23, 2021
Primary completion
Jun 1, 2021
Completion
Jun 1, 2021
Last update
Jun 2, 2021

Study contacts

Andreas Filippi, Prof. Dr. med. dent.
principal investigator · Universitäres Zentrum für Zahnmedizin Basel (UZB)

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.

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