An interventional study of transvertebral direct current stimulation (tvDCS) in Spinal Cord Injuries and Paraplegia and Tetraplegia, sponsored by University of Kentucky. Terminated at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2021-01-15.
Sponsored by University of Kentucky · Not applicable, Interventional, and Treatment
This study will evaluate the effects of non-invasive stimulation of the spinal cord in people with spinal cord injury.
This study will use a non-invasive form of spinal stimulation, called transvertebral direct current stimulation, or tvDCS. It currently is not clear what effects this type of stimulation has on the excitability of the brain and spinal cord in people with spinal cord injury. In this study, subjects will participate in 3 sessions, with at least 1 week in between sessions, during which they will get a different condition of tvDCS. We will test the excitability of the brain and spinal cord before and after tvDCS in each session.
1,948 studies on the registry are indexed under Spinal Cord Injuries; 505 are open to participants now.
This study's enrollment of 27 is above the median of 24 across 1,566 interventional studies indexed under Spinal Cord Injuries.
Browse Spinal Cord Injuries studies →University of Kentucky is the lead sponsor of 68 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
20 minutes of anodal tvDCS will be applied over the spine at 2.5mA.
Device: transvertebral direct current stimulation (tvDCS)
20 minutes of cathodal tvDCS will be applied over the spine at 2.5mA.
Device: transvertebral direct current stimulation (tvDCS)
20 minutes of sham tvDCS will be applied over the spine.
Device: transvertebral direct current stimulation (tvDCS)
tvDCS is a painless, non-invasive form of spinal stimulation which delivers safe, low levels of electrical current to the spinal cord through the back. It is believed to be able to influence the excitability of the brain and spinal cord.
Change in corticospinal excitability
This will be measured using transcranial magnetic stimulation to evoke responses in muscles of the lower leg.
Time frame: Immediately before tvDCS, Immediately after tvDCS
Change in spinal cord excitability
Hoffmann's reflex will be used to assess spinal cord excitability. For this text, pulses of electrical stimulation will be applied to the back of the knee and the response will be measured from the calf muscle.
Time frame: Immediately before tvDCS, Immediately after tvDCS
Plan to share: No
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This study is terminated, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
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