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CompletedNCT04561895Updated Sep 24, 2020

Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients

An observational study in NAFLD and NASH - Nonalcoholic Steatohepatitis, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2020-09-24.

Sponsored by Cairo University · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
224
Ages
18 Years to 60 Years
Sex
All
01

Study summary

Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also to find different related factors including obesitu, diabetes and liver enzymes level

02

Conditions studied

  • NAFLD
  • NASH - Nonalcoholic Steatohepatitis

Keywords

  • Egyptian population
  • NAFLD
  • NASH
  • DNA extraction
  • liver enzymes
03

In context

Fatty Liver

1,451 studies on the registry are indexed under Fatty Liver; 292 are open to participants now.

This study's enrollment of 224 is above the median of 140 across 397 observational studies indexed under Fatty Liver.

Browse Fatty Liver studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Sampling method
Probability sample

Study population

Egyptian diabetic patients diagnosed with NAFLD

Inclusion criteria

Egyptian patients confirmed NAFLD diagnosis diabetic

Exclusion criteria

-

Exclusion Criteria:

  • Pregnancy and lactation, history of alcohol abuse (as defined by an average daily consumption of alcohol > 30 g/day in men and > 20 g/day women), cirrhosis, autoimmune hepatitis and other causes of liver disease (viral hepatitis, hemochromatosis, Wilson's disease), drug induced hepatitis, chronic enteropathies, Chronic kidney disease
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
224 participants (actual)
Target follow-up
4 Weeks
Patient registry
Yes

Groups and cohorts

  • control group

    healthy volunteers with absence of NAFLD

    Genetic: DNA extraction

  • test group

    patients with confirmed NAFLD diagnosis

    Genetic: DNA extraction

Interventions

  • GeneticDNA extraction

    investigation of DNA polymorphism in patients suffering from NAFLD

06

What researchers measure

Primary outcomes

  1. investigate adipokine dna polymorphism

    to investigate adipokine gene polymorphism associated with prognosis of NAFLD patients

    Time frame: 1 months

  2. correlations

    to correlate between gene polymorphism and glycated hemoglobin, liver enzyme and obesity

    Time frame: 1 month

07

Study locations

1 site
  • El Sahel teaching hospital
    Cairo, Shobra 11311, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 24, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04561895
Lead sponsor
Cairo University
Collaborators
Elsahel teaching hospital
Responsible party
Dalia K. Zaafar (lecturer of pharmacology, Cairo University) — Principal investigator
First posted
Sep 24, 2020
Start date
Jan 1, 2020
Primary completion
Sep 15, 2020
Completion
Sep 16, 2020
Last update
Sep 24, 2020

Study contacts

Amal Ahmed, PhD
principal investigator · professor

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.

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