An interventional study of lung recruitment maneuver (LRM) with DrageerVN500 in Bronchopulmonary Dysplasia, sponsored by Dr. R. Adhi Teguh Perma Iskandar, Sp.A(K). Status unknown. Open to participants aged Up to 48 Hours. Per ClinicalTrials.gov, last updated 2020-09-21.
Sponsored by Dr. R. Adhi Teguh Perma Iskandar, Sp.A(K) · Not applicable, Interventional, and Prevention
hypothesis :
description of the protocol :
339 studies on the registry are indexed under Bronchopulmonary Dysplasia; 80 are open to participants now.
This study's planned enrollment of 110 is above the median of 70 across 228 interventional studies indexed under Bronchopulmonary Dysplasia.
Browse Bronchopulmonary Dysplasia studies →This is the only study on the registry with Dr. R. Adhi Teguh Perma Iskandar, Sp.A(K) as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
diaphragmatic hernia, atresia ani, esophageal atresia, duodenal atresia.
Born with congenital disorder that worsening of the respiratory distress (for example
The lung recruitment maneuver (LRM) will be done by increasing of PEEP 0,2 cm H2O every 3 minutes, until reach the opening pressure. After that PEEP decrease gradually until get the closing pressure. Than the investigators will back to the opening pressure for 3 minutes, and the final PEEP will be put backo 0,2 above closing pressure.
Device: lung recruitment maneuver (LRM) with DrageerVN500
Another group get standart protocol only.
interventions involving device that may help to gradually lung development
Knowing the relationship between lung recruitment maneuver in 24-32 weeks preterm babies with the incidence of Bronchopulmonary dysplasia
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will have lower incidence of Bronchopulmonary dysplasia compare to control.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weekers, with their alveolar intergrity (serum levels of surfactan protein-D)
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will have lower serum levels of surfactan protein -D compare to control.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weekers, with their lung endothel intergrity (serum levels of CD-31+)
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will have lower serum concentrarion of CD-31+ compare to control.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weeks preterm babies with their lung endothel intergrity (serum levels of CD-42b-)
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will have lower serum concentrarion of CD-42b- compare to control.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weeks preterm babies with their micro circulation (oxygen index)
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will have higher oxygen index compare to control.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weeks preterm babies with their their micro circulation (tc-pCO2 - PaCO2 index)
preterm babies ( 24-32 weeks) with Lung Recrutment manuver will have transcutaneous-arterial partial carbon dioxide gap lower than control ( less than 6 mmHg ). babies with better microcirculation status will show less than 6 mmHg transcutaneous-arterial partial carbon dioxide gap.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weeks preterm babies with their incidence patent ductus arteriosus (PDA) significant
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will make lower incident of Patent Ductus Arteriosus compare to control.
Time frame: 12 weeks
Knowing the relationship between lung recruitment maneuver in 24-32 weeks preterm babies with their macro circulation
Preterm babies ( 24-32 weeks) with Lung Recruitment maneuver will make right and left cardiac output higher compare to control.
Time frame: 12 weeks
No study locations are listed for this record.
Plan to share: No
This study is status unknown, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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