An interventional study of Transesophageal Echocardiography in Hyperthermia and Cardiac Functional Disturbances During Surgery, sponsored by University of California, San Diego. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-09-21.
Sponsored by University of California, San Diego · Not applicable, Interventional, and Supportive care
Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.
478 studies on the registry are indexed under Hyperthermia; 92 are open to participants now.
This study's enrollment of 28 is below the median of 60 across 365 interventional studies indexed under Hyperthermia.
Browse Hyperthermia studies →University of California, San Diego is the lead sponsor of 958 studies on the registry; 191 are open to participants now.
Of its 110 completed or terminated interventional studies of FDA-regulated products, 70 (64%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Placement of a transesophageal probe and performance of a diagnostic Transesophageal echocardiography examination.
Change in ejection fraction before and after hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Transmitral inflow velocities before and after hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Pulmonary venous inflow velocities before and during hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Mitral annular tissue doppler velocities before and during hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
heart rate before and during hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
mean arterial pressure before and during hyperthermia
Time frame: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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University of California, San Diego