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CompletedNCT04516798WBV-IRMUpdated Oct 27, 2020

The Reflex Mechanism Underlying Neuromuscular Effects Of The Whole Body Vibration

An interventional study of vibration in Reflex, Ankle, Decreased, sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital. Completed at 1 site in Turkey. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-10-27.

Sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
8
Allocation
Not applicable
Ages
20 Years to 40 Years
Sex
All
01

Study summary

This study was conducted to determine whether the spinal reflex mechanism underlying the neuromuscular effects of whole body vibration (WBV) is tonic vibration reflex. Local and whole body vibration reflex latencies were measured in young adult healthy volunteers.

Read the detailed description

A total of eight volunteers were included according to the inclusion and exclusion criteria. The subjects were vibrated while standing upright with the WBV device (PowerPlate® Pro5). The 30, 35 and 40 Hz WBVs were applied for thirty seconds for each frequency with an amplitude of 2 mm. In the same session, 100, 135 and 150 Hz local vibrations were applied to the right Achilles tendon for thirty seconds for each frequency. 100, 135 and 150 Hz local vibrations were then applied to the right heel for thirty seconds for each frequency with an interval of five seconds. Vibration stimuli were recorded accelerometers. Reflex muscle responses were recorded from the right soleus muscle at a sampling rate of 40 KHz. Recording electrodes were placed on the belly of the right soleus muscle and the ground electrode was placed on the right medial malleolus.

The data were recorded with the PowerLab device, the records were processed and analyzed offline from the LabChart program. After the EMG records are filtered and rectified, reflex latencies were measured by cumulative averaging method using the accelerometer records as triggers (Karacan I, Cakar HI, Sebik O, Yilmaz G, Cidem M, Kara S, Türker KS.A new method to determine reflex latency induced by high rate stimulation of the nervous system.Front Hum Neurosci.2014 Jul 18; 8: 536.doi: 10.3389 / fnhum.2014.00536). After determining the Achilles tendon vibration reflex latency and the reflex latency induced by WBV, it was compared with statistical methods.

02

Conditions studied

  • Reflex, Ankle, Decreased

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Keywords

  • whole body vibration
  • tonic vibration reflex
  • muscle spindle
03

In context

Reflex, Abnormal

18 studies on the registry are indexed under Reflex, Abnormal; 1 is open to participants now.

This study's enrollment of 8 is below the median of 16 across 13 interventional studies indexed under Reflex, Abnormal.

Browse Reflex, Abnormal studies →

Lead sponsor

Istanbul Physical Medicine Rehabilitation Training and Research Hospital is the lead sponsor of 123 studies on the registry; 26 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy
  • Young adult (20-40 years old)
  • Both gender
  • Volunteer

Exclusion criteria

Exclusion Criteria:

  • Cardiac disorder (Rhythm / conduction disorder, Cardiac pacemaker, Ischemic heart disease)
  • Finding or suspected active deep vein thrombosis,
  • History of deep vein thrombosis and pulmonary embolism,
  • Orthostatic hypotension
  • Hypertension
  • Presence of fracture in the lower limb
  • Achilles Contractures
  • Active inflammatory, rheumatological or infectious disease in the lower limb
  • Peripheral nerve lesions such as polyneuropathy, radiculopathy in the lower limb
  • Those with a history of Achilles tendinopathy / bursitis
  • Those with a history of kidney stones
  • Patients with dizziness and balance problems,
  • Cases with lesions on the skin surface where electrodes were attached
  • Those with communication-cooperation problems
  • Having a history of panic attacks
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
8 participants (actual)

Study arms

  • Experimental
    Experiment

    Local and whole body vibration were applied

    Other: vibration

Interventions

  • Othervibration

    local and whole-body vibration were applied

06

What researchers measure

Primary outcomes

  1. reflex latency

    The time between the vibration stimulus and the reflex muscle response triggered by it was defined as the latency.

    Time frame: during intervention, an average of 8 minutes

07

Study locations

1 site
  • Istanbul Physical Medicine Rehabilitation Training & Research Hospital
    İstanbul, 34173, Turkey
08

References and documents

Publications

  • Yildirim MA, Topkara B, Aydin T, Paker N, Soy D, Coskun E, Ones K, Bardak A, Kesiktas N, Ozyurt MG, Celik B, Onder B, Kilic A, Kucuk HC, Karacan I, Turker KS. Exploring the receptor origin of vibration-induced reflexes. Spinal Cord. 2020 Jun;58(6):716-723. doi: 10.1038/s41393-020-0419-5. Epub 2020 Jan 15. PubMed 31942042 ↗
  • Aydin T, Kesiktas FN, Baskent A, Karan A, Karacan I, Turker KS. Cross-training effect of chronic whole-body vibration exercise: a randomized controlled study. Somatosens Mot Res. 2020 Jun;37(2):51-58. doi: 10.1080/08990220.2020.1720635. Epub 2020 Feb 5. PubMed 32024411 ↗
  • Karacan I, Cakar HI, Sebik O, Yilmaz G, Cidem M, Kara S, Turker KS. A new method to determine reflex latency induced by high rate stimulation of the nervous system. Front Hum Neurosci. 2014 Jul 18;8:536. doi: 10.3389/fnhum.2014.00536. eCollection 2014. PubMed 25100978 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Oct 2020 to primary completion in Oct 2020, 0 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 14, 2020
First posted
Aug 18, 2020
StartActual
Oct 5, 2020
Primary completionActual
Oct 7, 2020
CompletionActual
Oct 7, 2020
Last update
Oct 27, 2020
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 27, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04516798
Responsible party
Sponsor
First posted
Aug 18, 2020
Start date
Oct 5, 2020
Primary completion
Oct 7, 2020
Completion
Oct 7, 2020
Last update
Oct 27, 2020

Study contacts

Ilhan Karacan, Assoc Prof
principal investigator · Istanbul Physical Medicine Rehabilitation Training & Research Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.

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