An interventional study of Covert Saccades and Virtual Reality and Actives versus passives Head Impulses in Reflex, Abnormal, Bilateral Vestibulopathy and Healthy Volunteers, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-02.
Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Basic science
Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The triggering of these covert-saccade is still not known. They could be of visual origin but the short latency is unusual. The objective of this study is to evaluate the potential role of visual trigger in 12 patients with chronic bilateral areflexia, using different visuo-vestibular conditions. The latency of simple visually guided saccades will also be tested in the group of patients and a group of 12 healthy controls.
18 studies on the registry are indexed under Reflex, Abnormal; 1 is open to participants now.
This study's enrollment of 32 is above the median of 16 across 13 interventional studies indexed under Reflex, Abnormal.
Browse Reflex, Abnormal studies →Hospices Civils de Lyon is the lead sponsor of 1,866 studies on the registry; 448 are open to participants now.
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Bilateral vestibular hypofunction with regards to the criteria of the of the Barany Society A. Chronic vestibular syndrome with at least three of the following symptoms
Worsening of postural imbalance or unsteadiness of gait in darkness and/or on uneven ground B. No symptoms while sitting or lying down under static conditions C. Bilaterally reduced or absent angular VOR function documented by
D. Not better accounted for by another disease
* For Healthy control No ENT or neurological disorders
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients suffering from chronic bilateral vestibular hypofunction
Other: Covert Saccades and Virtual Reality · Other: Actives versus passives Head Impulses · Other: Visually guided saccades
Other: Covert Saccades and Virtual Reality · Other: Actives versus passives Head Impulses · Other: Visually guided saccades
During this intervention, patients will undergo head impulse testing while wearing virtual reality Headsets. During the head impulse tests the visual information will be modified in order to create a conflict between head rotation and rotation of the visual scene. Recording of head and eye movement will be done during these head impulses in order to verify if visual information modifies compensatory eye movements during head impulses.
Patients will undergo classic passive head rotation as well as active head rotation in order to compare latencies of covert saccades in both conditions.
Patients as well as healthy control subjects will undergo testing of visually guided saccades in different conditions (step, gap, overlap) in order to compare latencies of covert saccades between both groups.
Latency of covert-saccades
Latency of covert saccades correspond to the time between the beginning of head impulse and the initiation of the first covert-saccade
Time frame: Day 1
Frequency of covert-saccades
Frequency of covert saccades corresponds to the total amount of covert-saccades divided by the total amount of head impulse tests multiplied by 100.
Time frame: Day 1
Velocity of covert-saccades
Velocity of covert saccades correspond to the maximal velocity of the first covert-saccade
Time frame: day 1
Amplitude of covert-saccades
Amplitude of covert saccades correspond to amplitude of the first covert-saccade
Time frame: Day 1
Latency of visually-guided saccades
Latency of visually guided saccades correspond to the time between the appearance of target and the initiation of the first saccade
Time frame: Day 1
Ran from Dec 2020 to primary completion in Mar 2022, 15 months.
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This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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