An interventional study of Blood collection for genetic analysis in Takotsubo Cardiomyopathy, sponsored by University of Aberdeen. Recruiting at 2 sites in United Kingdom. Per ClinicalTrials.gov, last updated 2026-04-30.
Sponsored by University of Aberdeen · Not applicable, Interventional, and Other
Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.
Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.
61 studies on the registry are indexed under Takotsubo Cardiomyopathy; 25 are open to participants now.
This study's planned enrollment of 700 is above the median of 66 across 23 interventional studies indexed under Takotsubo Cardiomyopathy.
Browse Takotsubo Cardiomyopathy studies →University of Aberdeen is the lead sponsor of 170 studies on the registry; 23 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
A patient that has been diagnosed with Takotsubo Cardiomyopathy from 2010 onwards.
Genetic: Blood collection for genetic analysis
Blood collection for genetic analysis
Genome Wide Association Study
Genome Wide Association Study to search for susceptibility variants
Time frame: At baseline
Plan to share: No
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University of Aberdeen