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CompletedNCT04496570Updated Aug 19, 2020

Resolvin D1 Levels in Patients With Periodontitis

An interventional study of periodontal therapy in Periodontitis, sponsored by T.C. ORDU ÜNİVERSİTESİ. Completed at 1 site in Turkey. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-08-19.

Sponsored by T.C. ORDU ÜNİVERSİTESİ · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Registered 11 months after the study started (first participant enrolled Jul 2019, registered Jul 2020).
Phase
Not applicable
Study type
Interventional
Enrollment
26
Allocation
Non-randomized
Ages
30 Years to 60 Years
Sex
All
01

Study summary

The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

02

Conditions studied

  • Periodontitis

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Keywords

  • gingival crevicular fluid
  • resolvin D1
03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's enrollment of 26 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

T.C. ORDU ÜNİVERSİTESİ is the lead sponsor of 87 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Stage 3, Grade B and generalized periodontitis patients

Exclusion criteria

Exclusion Criteria:

  • excessive forces;
  • presence of systemic diseases
  • administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
  • having received non-surgical periodontal treatment within the past 6 months
  • allergy or sensitivity to any drug,
  • pregnancy, lactation
  • current and former use of tobacco.
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
26 participants (actual)

Study arms

  • Active comparator
    Periodontitis patients

    gingival crevicular fluid and saliva collection were taken before and after nonsurgical periodontal treatment

    Procedure: periodontal therapy

  • No intervention
    Healthy individuals

    gingival crevicular fluid and saliva collection were taken at baseline after oral hygiene instructions

Interventions

  • Procedureperiodontal therapy

    Non surgical periodontal therapy was performed to patients with peridontitis

06

What researchers measure

Primary outcomes

  1. Biochemical parameter (resolvin D1)

    The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.

    Time frame: Baseline and 1 month after NSPT

Secondary outcomes

  1. Probing pocket depth

    The changes in probing pocket depth after periodontal treatment were evaluated

    Time frame: Baseline and 1 month after NSPT

  2. Clinical attachment level (CAL)

    The changes in CAL after periodontal treatment were evaluated

    Time frame: Baseline and 1 month after NSPT

  3. Plaque index (PI)

    The changes in PI after periodontal treatment were evaluated

    Time frame: Baseline and 1 month after NSPT

  4. Gingival index (GI)

    The changes in GI after periodontal treatment were evaluated

    Time frame: Baseline and 1 month after NSPT

07

Study locations

1 site
  • Ordu University
    Ordu, 52200, Turkey
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 19, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04496570
Lead sponsor
T.C. ORDU ÜNİVERSİTESİ
Responsible party
Ceren Gökmenoğlu (Principal investigator, T.C. ORDU ÜNİVERSİTESİ) — Principal investigator
First posted
Aug 3, 2020
Start date
Jul 31, 2019
Primary completion
Feb 29, 2020
Completion
Feb 29, 2020
Last update
Aug 19, 2020

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2020. You cannot join it, but the record below documents what was studied.

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