An interventional study of Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group. in Thyroid Nodule, sponsored by Bezmialem Vakif University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 76 Years. Per ClinicalTrials.gov, last updated 2020-07-23.
Sponsored by Bezmialem Vakif University · Not applicable, Interventional, and Supportive care
The aim of the study was to investigate the functional and morphological effects of Anethum graveolens L. in patients with thyroiditis and nodular goiter by evaluating hormone levels, anti-Inflammatory markers and comparing thyroid nodule sizes measured by ultrasonography for 90 days.
The effect of Anethum graveolens L. was evaluated in euthyroid goiter patients diagnosed with benign thyroid nodule via fine needle aspiration biopsy. Aerial parts of Anethum graveolens L. were dried and grinded to yield a fine powder. Size 1 hydroxypropyl methylcellulose capsules were filled with 300 mg powder. Placebo was prepared in the same manner using maltodextrin. Patients were suggested to take 3 pills a day. Blood samples were collected at the initial and the final day for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (Anti-Tg) and C-reactive protein (CRP) analysis. Nodule sizes were also measured at the beginning and at the end of the trial with ultrasonography to identify the changes and effectiveness of dill dosage forms.
After 90 days in the study, the status of TSH, fT3, fT4, anti-TPO and CRP levels were examined in the group with and without Anethum graveolens L..
Again, after the study, the size of thyroid nodules was evaluated in the group who received and did not receive Anethum graveolens L. by ultrasonography.
207 studies on the registry are indexed under Thyroid Nodule; 64 are open to participants now.
This study's enrollment of 68 is close to the median of 75 across 121 interventional studies indexed under Thyroid Nodule.
Browse Thyroid Nodule studies →Bezmialem Vakif University is the lead sponsor of 354 studies on the registry; 59 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
They took 3 meals a day, 3x300 mg dry dill powder by mouth. They bought dry dill powder for 90 days.
Dietary Supplement: Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.
They took 3 meals a day and 3 cellulose placebo capsules by mouth. They took placebo capsules for 90 days.
Dietary Supplement: Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.
Tests from intravenous blood: TSH, fT3, fT4, anti-TPO, Anti-Tg, CRP
Also known as: Taking blood from the arm intravenously at the beginning and end of the study and looking for thyroid hormones from this blood.
Comparison of thyroid stimulating hormone (TSH) between groups
At the beginning and at the end of the study, the levels of serum TSH were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Comparison of free triiodothyronine (fT3) between groups
At the beginning and at the end of the study, the levels of serum fT3 were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Comparison of free thyroxine (fT4) between groups
At the beginning and at the end of the study, the levels of serum fT4 were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Comparison of anti-thyroid peroxidase (anti-TPO) between groups
At the beginning and at the end of the study, the levels of anti-TPO were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Comparison of anti-thyroglobulin (Anti-Tg) between groups
At the beginning and at the end of the study, the levels of serum Anti-Tg were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Comparison of C-reactive protein (CRP) between groups
At the beginning and at the end of the study, the levels of serum CRP were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Comparison of ultrasound and thyroid nodule sizes between groups
At the beginning and end of the study, thyroid nodule sizes (mm) were measured and statistically compared in groups given Anethum graveolens L. and placebo.
Time frame: 90 days
Plan to share: No — When published as a full article in a journal indexed, IPD will be shared.
Ran from Feb 2019 to primary completion in Dec 2019, 10 months.
Of 67 non-industry interventional studies with no phase under Thyroid Nodule, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 46. This study's 10 months is below that.
Counting every sponsor, half of 71 studies reached it within 30 months; a quarter within 14 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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