An interventional study of Pulmonary rehabilitation therapy in Pulmonary Disease, sponsored by Chinese PLA General Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by Chinese PLA General Hospital · Not applicable, Interventional, and Treatment
Evaluation of the effect of pulmonary rehabilitation on patients with high flow oxygen therapy
Objective: the purpose of this study was to evaluate the effect of lung rehabilitation on patients treated with high flow humidification apparatus in ICU. Methods: 70 patients in ICU who were treated with high flow humidification apparatus from June 2019 to June 2020 were randomly divided into two groups. The experimental group was treated with pulmonary rehabilitation and the control group was treated with routine medical treatment only. All patients were evaluated and measured by bedside diaphragm ultrasound. The vital signs of all patients were monitored every day. MRCsum assessment of peripheral muscle strength, 30s sitting test, modified Barthel index, Borg dyspnea score, arterial blood gas analysis and bedside diaphragm ultrasound monitoring were performed at admission and discharge. Finally, statistics were made on the use of non-invasive ventilator, endotracheal intubation, new complications (pressure sore, aspiration, thrombus, etc.) and the time of patients getting out of bed for the first time.The end point of the experiment was 28 days.
3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.
This study's planned enrollment of 70 is close to the median of 72 across 2,118 interventional studies indexed under Lung Diseases.
Browse Lung Diseases studies →Chinese PLA General Hospital is the lead sponsor of 558 studies on the registry; 202 are open to participants now.
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Exclusion Criteria:
Pulmonary rehabilitation therapy
Behavioral: Pulmonary rehabilitation therapy
Routine medical treatment
Comprehensive interventions based on comprehensive evaluation and customization of patients, including, but not limited to, exercise training, education and behavioral changes, aimed at improving the physiological and psychological status of patients with chronic respiratory diseases, and urge patients to adhere to health promotion activities for a long time.
MRC
Medical Research Council,Muscle strength assessment,total points0\~60，less than 48scores means ICU aquired weaknesses.
Time frame: Day 28
STS
Number of sit-to-stand test in 30s,Muscle endurance assessment,The more times, has the better muscular endurance.
Time frame: Day 28
barthel index
barthel index,Daily activity assessment,Assessment of activities of daily living.total points0\~100，less than 60 scores means can't independent living.
Time frame: Day 28
Borg dyspnea score
Borg dyspnea score,Maximum 10 points,Minimum 0,The higher the score, the harder it is to breathe
Time frame: Day 28
PaO2
arterial partial pressure of oxygen,Partial pressure of oxygen in arterial blood,normal range is 80\~100.
Time frame: Day 28
Oxygenation index
arterial partial pressure of oxygen divided by the oxygen concentration,Normal is greater than 400.
Time frame: Day 28
Diaphragm mobility
The distance the diaphragm drops during inhalation,normal is 1.4cm.
Time frame: Day 28
Diaphragm contraction velocity
The rate at which the diaphragm contracts during inhalation,normal is 1.3cm/s.
Time frame: Day 28
End-inspiratory diaphragm thickness
The thickness of the diaphragm during inhalation,The thickness of diaphragm at the end of expiratory is about 0.25cm.
Time frame: Day 28
End-expiratory diaphragm thickness
The thickness of the diaphragm during exhalation,The thickness of diaphragm at the end of expiratory is about 0.15cm.
Time frame: Day 28
Diaphragm thickness variation rate
Rate of diaphragmatic thickness change during breathing,Diaphragmatic dysfunction is considered less than 20%.
Time frame: Day 28
ICU stay time
icu length of stay
Time frame: 3 month
Hospitalization time
Hospitalization time,length of stay in hospital.
Time frame: Month 3
The time it takes to get out of bed for the first time
The time it takes to get out of bed for the first time
Time frame: Day 28
Use of non-invasive ventilator
Use of non-invasive ventilator,Whether to use non-invasive ventilator within 28 days.
Time frame: Day 28
Intubation
Intubation,Whether endotracheal intubation was performed for invasive mechanical ventilation within 28 days
Time frame: Day 28
mortality
mortality
Time frame: Day 28
Complication
The incidence of new complications(pressure sores、thrombus、aspiration).
Time frame: Day 28
Plan to share: No
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Chinese PLA General Hospital