An observational study in Cushing Syndrome and Hypercortisolism, sponsored by Marmara University. Status unknown at 1 site in Turkey. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-16.
Sponsored by Marmara University · Observational
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
Endogenous Cushing's syndrome (CS) is associated with increased macrovascular diseases and impaired endothelial function. There is no clear data about the effects of hypercortisolism on microcirculation.
The primary aim of this study is to evaluate the peripheric microvascular area in patients with Cushing's syndrome. The association of microvascular changes with present comorbidities (diabetes, hypertension, etc.) and disease activation will be evaluated.
Method:
Cushing syndrome patients admitted to our clinic will be included in this study for the next six months after given informed consent.
The following clinical laboratory parameters will be evaluated as cross-sectionally.
Previous medical history, available laboratory parameters (fasting plasma glucose, HbA1c, total cholesterol, triglyceride, HDL, LDL, creatine, AST, ALT, complete blood count, ACTH, dexamethasone suppression tests (1 mg- 2mg), urine free cortisol, FSH, LH, total testosterone, estradiol, IGF-1, TSH, free T3, free T4, prolactin), radiologic images (Cranial MRI and Adrenal MRI) will be recorded from medical charts.
Nailfold microcirculation will be evaluated with video-capillaroscopy: it is a non-invasive atraumatic assessment of the morphology and some functional aspects of cutaneous capillaries.
Patients with diagnosed as endogenous Cushing syndrome, and age and sex matched controls
Exclusion Criteria:
Male and female patients diagnosed as Cushing syndrome caused by ACTH-producing pituitary adenoma or cortisol producing adrenal adenoma
Healthy controls matched for age, gender, and body mass index
Nailfold capillary number of tortuous loops
Nailfold capillary area changes
Time frame: 6 months
Nailfold capillary area number of meandering capillaries
Nailfold capillary area changes
Time frame: 6 months
Nailfold capillary avascular areas
Nailfold capillary area changes
Time frame: 6 months
Correlation between nailfold capillary number of tortuous loops and presence of diabetes
Independent risk factors that affected nailfold capillaroscopy images
Time frame: 6 months
Correlation between nailfold capillary number of tortuous loop with urine free cortisol levels
Presence and severity of hypercortisolism as an independent risk factor
Time frame: 6 months
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Jun 2020. You cannot join it, but the record below documents what was studied.
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Marmara University