An observational study in Covid-19, Health Personnel and Personnel, Hospital, sponsored by Nordsjaellands Hospital. Recruiting at 2 sites in Denmark. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-16.
Sponsored by Nordsjaellands Hospital · Observational
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital. This will enable the identification of those who are protected and non-infectious for SARS-CoV2 and those who are seronegative and therefore potentially susceptible and infectious on patient contact. Prospective testing will provide data on the acquisition of SARS-CoV2 infections among HCWs and associated risk factors for transmission during a pandemic at an acute care hospital facility in the capital region of Denmark.
Hypothesis: Serial seroconversion measurements in hospital employees improve the organization of the clinical treatment and care during the COVID-19 pandemic at Nordsjællands Hospital and Nykøbing Falster County Hospital.
The study is a prospective cohort study. Weekly (in the first phase) and bi-weekly (in the second phase) serum samples will be drawn and shipped bi-weekly to laboratory collaborators in United Kingdom for antibody analyses during the course of the local epidemic, expected to last 10-12 weeks or more. After the cease of the epidemic serum will be drawn in 3-monthly intervals in a smaller group of seroconverted volunteers to follow the long-lasting immunity of SARS-CoV-2 infection up to 5 years post-pandemic.
Nurses, medical doctors, biomedical laboratory scientists, social health care assistants, and few healthcare administrators (as controls) will be invited for enrolment. In hospitals, all departments with staff that are in physical contact with patients during the pandemic will be invited to participate in the study.
7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's planned enrollment of 300 is above the median of 260 across 3,135 observational studies indexed under COVID-19.
Browse COVID-19 studies →Nordsjaellands Hospital is the lead sponsor of 88 studies on the registry; 21 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Health care workers at two Danish hospitals
Inclusion Criteria: hospital employee
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Exclusion Criteria: none
Serial seroconversion measurements in hospital employees during the COVID-19 pandemic
Other: Serial seroconversion measurements in hospital employees during the COVID-19 pandemic
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital.
Serology testing for specific COVID-19
IgM and IgG (Covid-19 antibodies)
Time frame: From baseline to follow up at four years
SARS-CoV-2 infection
Swab, SARS-CoV-2
Time frame: From baseline to follow up at three months
Co-variates
Age, gender, employment details, smoking, chronic diseases
Time frame: At baseline
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Nordsjaellands Hospital