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CompletedNCT04422158Updated Apr 28, 2021

Impact of Nuun Electrolyte Tablets on Hydration Status in Active Men and Women

An interventional study of Nuun electrolyte tablet and water in Hydration, sponsored by University of Memphis. Completed at 1 site in United States. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-04-28.

Sponsored by University of Memphis · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The purpose of this study is to determine the impact of Nuun electrolyte tablets on hydration status in young and active men and women. We will follow a similar approach as used by Maughan and colleagues (2016) to measure the beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water). It is hypothesized that Nuun electrolyte tablets will result in a greater hydration status as compared to water only. Due to the fact that athletes use Nuun tablets at varying dosages, we will evaluate Nuun at both a single dosage and a double dosage. We maintain a non-directional hypothesis regarding the potential differences between the two different dosages tested.

Read the detailed description

Maintaining adequate hydration is essential to optimal health and athletic performance. When individuals exercise (in particular in a warm environment), they can lose excessive amounts of fluids through sweating, along with necessary electrolytes (e.g., sodium, potassium, chloride). With dehydration, individuals may feel sluggish and can experience impaired physical performance.

Many attempts have been made to improve and measure the hydration status of active individuals. This typically involves the ingestion of fluids leading up to activity (typically plain water), as well as the ingestion of fluids during the activity itself (water, along with a diluted carbohydrate/electrolyte beverage). This approach seems to work well; however, some debate remains over what the best fluid is to consume, in particular related to the macronutrient type and the specific electrolyte mix.

Related to the above, it is well-accepted that electrolyte replenishment is of importance, both during and following exercise-to aid in rehydration for subsequent bouts. The use of electrolytes (sodium in particular) has been used for decades to aid athlete hydration and has led to the development of various sport drinks-which also include small amounts of carbohydrate. However, one problem with carbohydrate ingestion is that some individuals experience gastrointestinal (GI) upset following carbohydrate ingestion before and during an event, despite very good physical performance outcomes. Due to this GI upset, some individuals (in particular recreationally active individuals who are not competing at high levels) rely solely on water and seek a method to ingest the lost electrolytes. In addition, some individuals prefer to have both plain water and an electrolyte beverage during their training/competition sessions and in some activities (e.g., running, cycling), carrying multiple bottles of fluid is difficult.

The solution to the above issues for many athletes is the use of electrolyte tablets. These can be dropped into plain water and will dissolve into a flavored electrolyte-rich beverage. They are easy to transport and provide the needed electrolytes to replace those that are lost through intense and/or long duration exercise.

Nuun electrolyte tablets provide only 2 grams of carbohydrate and a combination of electrolytes, provided at a relatively low percentage of the Daily Value (DV). The DV tells us how much a particular nutrient in a serving of a food product contributes to a daily diet, based on a standard 2000 calorie diet. Nuun tablets contain: calcium (13mg, 1%DV), sodium (300mg, 13%DV), potassium (150mg, 3%DV), magnesium (25mg, 6%DV), and chloride (40mg, 2%DV). These tablets contain a small percentage of the needed total electrolytes but adequate amounts to replace lost electrolytes as a result of physical activity.

While Nuun tablets are commercially available and have received positive reviews from end users, there have been no studies to date to evaluate the impact of these tablets on hydration status. Therefore, the purpose of this study is to determine the impact of Nuun electrolyte tablets on hydration status in young and active men and women. We will follow a similar approach as used by Maughan and colleagues to measure the beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water). It is hypothesized that Nuun electrolyte tablets will result in a greater hydration status as compared to water only. Due to the fact that athletes use Nuun tablets at varying dosages, we will evaluate Nuun at both a single dosage and a double dosage. We maintain a non-directional hypothesis regarding the potential differences between the two different dosages tested.

02

Conditions studied

  • Hydration

Keywords

  • electrolyte
03

In context

Lead sponsor

University of Memphis is the lead sponsor of 44 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • BMI between 18.5 and 29.9 kg/m2 (not obese)
  • Consumes 2 liters of water daily
  • Exercised 3 hours/week over the past 6 months

Exclusion criteria

Exclusion Criteria:

  • Obese
  • Pregnant or trying to become pregnant
  • Tobacco user
  • Cardiac Disease
  • Consumed alcohol within 48 hours of testing visit
  • Consumed caffeine within 48 hours of testing visit
  • Strenuous excercise 24 hours prior to testing visit
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
20 participants (actual)

Study arms

  • Experimental
    Nuun Single strength

    3 Nuun electrolyte tablets will be dissolved in 1.4 liters of water. Subjects will drink one liter of the prepared solution over 30 min (250 mL every 7.5 min)

    Dietary Supplement: Nuun electrolyte tablet · Other: water

  • Experimental
    Nuun Double strength

    6 Nuun electrolyte tablets will be dissolved in 1.4 liters of water. Subjects will drink one liter of the prepared solution over 30 min (250 mL every 7.5 min)

    Dietary Supplement: Nuun electrolyte tablet · Other: water

  • Placebo comparator
    Control

    Subjects will drink one liter of water over 30 min (250 mL every 7.5 min)

    Other: water

Interventions

  • Dietary supplementNuun electrolyte tablet

    Each table contains 2 grams of carbohydrate and a combination of electrolytes. calcium (13mg, 1%DV), sodium (300mg, 13%DV), potassium (150mg, 3%DV), magnesium (25mg, 6%DV), and chloride (40mg, 2%DV).

  • Otherwater

    water

06

What researchers measure

Primary outcomes

  1. Body weight

    Body weight will be measured

    Time frame: baseline

  2. Body weight

    Body weight will be measured

    Time frame: 4 hours after drink consumption

  3. Urine volume

    Volume of urine output will be measured

    Time frame: Immediately after completing intervention

  4. Urine volume

    Volume of urine output will be measured

    Time frame: 1 hour after intervention

  5. Urine volume

    Volume of urine output will be measured

    Time frame: 2 hours after intervention

  6. Urine volume

    Volume of urine output will be measured

    Time frame: 3 hours after intervention

  7. Urine volume

    Volume of urine output will be measured

    Time frame: 4 hours after intervention

  8. Urine mass

    Urine output will be measured using a scale

    Time frame: Immediately after completing intervention

  9. Urine mass

    Urine output will be measured using a scale

    Time frame: 1 hour after intervention

  10. Urine mass

    Urine output will be measured using a scale

    Time frame: 2 hours after intervention

  11. Urine mass

    Urine output will be measured using a scale

    Time frame: 3 hours after intervention

  12. Urine mass

    Urine output will be measured using a scale

    Time frame: 4 hours after intervention

  13. Blood Pressure

    Blood pressure will be measured.

    Time frame: at baseline

  14. Blood Pressure

    Blood pressure will be measured.

    Time frame: 1 hour after intervention

  15. Blood Pressure

    Blood pressure will be measured.

    Time frame: 2 hours after intervention

  16. Blood Pressure

    Blood pressure will be measured.

    Time frame: 3 hours after intervention

  17. Blood Pressure

    Blood pressure will be measured.

    Time frame: 4 hours after intervention

  18. Heart Rate

    Heart Rate will be measured

    Time frame: baseline

  19. Heart Rate

    Heart Rate will be measured

    Time frame: 1 hour after intervention

  20. Heart Rate

    Heart Rate will be measured

    Time frame: 2 hours after intervention

  21. Heart Rate

    Heart Rate will be measured

    Time frame: 3 hours after intervention

  22. Heart Rate

    Heart Rate will be measured

    Time frame: 4 hours after intervention

07

Study locations

1 site
  • Center for Nutraceutical and Dietary Supplement Research
    Memphis, Tennessee 38152, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 28, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04422158
Lead sponsor
University of Memphis
Collaborators
Nuun & Company, Inc (Nuun)
Responsible party
Richard Bloomer (Dean of School of Health Studies, University of Memphis) — Principal investigator
First posted
Jun 9, 2020
Start date
Jun 3, 2020
Primary completion
Aug 18, 2020
Completion
Aug 18, 2020
Last update
Apr 28, 2021

Study contacts

Richard Bloomer, PhD
principal investigator · University of Memphis

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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