An observational study in COVID and Sars-CoV2, sponsored by Hospital Ambroise Paré Paris. Status unknown at 1 site in France. Per ClinicalTrials.gov, last updated 2021-04-29.
Sponsored by Hospital Ambroise Paré Paris · Observational
Critical care echocardiography (CCE) has been widely used since the 10 last years. Covid outbreak leads that many patients with acute respiratory failure were admitted in the ICU. Many of these patients were ventilated and developed ARDS. Some of them developed deep vein thrombosis and pulmonary embolism. Nothing is already described about the cardiac function and the hemodynamics in these patients (how many RV failure, LV systolic dysfunction,...). The echo group of the cardiodynamix section of European society of intensive care medicien (ESICM) aims to promote CCE and evaluate its interest. The objective is to retrospectively enter in an international database all the echo studies done as usual care in these patients to evaluate (i) incidence of RV failure, (ii) incidence of LV systolic function, (iii) incidence of other patterns. Another objective will be to look for any association between some patterns and respiratory strategy, blood gas analysis, systemic hemodynamics. The echo studies were done and will be reported following one of the recent systematic review published by the same group (Huang S et al. AOIC 2020).
Multicenter, international observational retrospective study. Patients admitted in the ICU between March 1th and april 26th for a pneumonia related to SARS COV 2 and who had at least one echocardiography during their stay will be included. Analysis will be retrospective in order to report the hemodynamic profile with left ventricular and right ventricular function. Will be also reported the respiratory settings, the central venous presure if available as well as usual parameters of macrocirculation. All data will be reported in RedCap by the University of sydney (https://redcap.sydney.edu.au/).
2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.
This study's planned enrollment of 1,500 is above the median of 203 across 688 observational studies indexed under Pneumonia.
Browse Pneumonia studies →Hospital Ambroise Paré Paris is the lead sponsor of 23 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
COVID 19 patients admitted in the ICU for respiratory failure.
Inclusion Criteria: patients admitted in the ICU for pneumonia related to SARS COV2 and who had at least 1 critical care echocardiography during the first 28 days.
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Exclusion Criteria: Patients who did not have any critical care echocardiography during the first 28 days of the ICU stay.
Incidence of Left ventricular systolic dysfunction
LV systolic dysfunction is defined as an ejection fraction \< 45%
Time frame: Up to 28 days
Incidence of RV failure
RV failure is defined as RV/LV end-diastolic area \> 0.8
Time frame: up to 28 days
Incidence of Vasoplegia
Vasoplegia is defined as a normal or supranormal LV ejection fraction without echocarduiographic signs of hypovolemia.
Time frame: Up to 28 days
Incidence of Hypovolemia
Hypovolemia is defined as inspiratory collaspe of the superior vena cava in ventilated patients or virtual inferior vena cava in spontaneously breathing patients.
Time frame: Up to 28 days
Relation between plateau pressure and RV failure
Plateau pressure and RV size
Time frame: Up to 28 days
Relation between tidal volume and RV failure
Tidal volume and RV size
Time frame: Up to 28 days
Relation between PaO2 and RV failure
PaO2, PaO2/FiO2, and RV size
Time frame: Up to 28 days
Relation between PaCO2 and RV failure
PaCO2 and RV size
Time frame: Up to 28 days
Relation between PEEP and RV failure
PEEP and RV size
Time frame: Up to 28 days
This study is status unknown, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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Hospital Ambroise Paré Paris