An observational study in Cardiac Toxicity, Acute Leukemia and Childhood Cancer, sponsored by Air Force Military Medical University, China. Completed at 1 site in China. Open to participants aged 1 Year to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-01.
Sponsored by Air Force Military Medical University, China · Observational
Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.
264 studies on the registry are indexed under Cardiotoxicity; 71 are open to participants now.
This study's enrollment of 300 is above the median of 100 across 125 observational studies indexed under Cardiotoxicity.
Browse Cardiotoxicity studies →Air Force Military Medical University, China is the lead sponsor of 172 studies on the registry; 36 are open to participants now.
Counted across the registry records on this site, refreshed daily.
A total of 300 eligible acute leukemia patients were anticipated to include in this study.
Exclusion Criteria:
300 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy
Diagnostic Test: Relative telomere length
Relative telomere length in peripheral blood cell
Relative telomere length
The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL.
Time frame: From date of admission until the date of discharging from hospital, assessed up to 5 days
Plan to share: No
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This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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Air Force Military Medical University, China