An interventional study of Sitting and Standing in Energy Expenditure and Metabolic Health, sponsored by National Taiwan Normal University. Completed at 1 site in Taiwan. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-05-15.
Sponsored by National Taiwan Normal University · Not applicable, Interventional, and Basic science
The purpose of this study is to investigate whether self-selected neuromuscular stimulation (NMES) affects energy expenditure, glycaemia and hormonal responses in healthy men and women
Participants were asked to perform 3 trials [sitting (SIT), standing (STAND) and sitting with neuromuscular electrical stimulation (NMES) to the lower limbs in randomised counter-balanced study design. Trials were separated by at least 48 h and were completed within 14 days. In all trials, participants were required to remain relaxed and motionless. SIT: participants sat in a chair with back, arms and legs supported. STAND: participants were asked to stand with arms supported and feet spaced approximately 15 cm apart. If needed, adjustment of standing posture was allowed during the standing trial to prevent orthostatic hypotension. NMES: prior to the NMES trial, participants underwent preliminary testing to ensure that stimulation was comfortable. Before the NMES, a small area of the body hair was shaved and skin was cleaned with an alcohol wipe and electrodes were stuck to the surface of the skin. Small electrodes placed (5*5 cm) on the lower limb of both legs (gastrocnemius, rectus femoris, vastus medialis). The two devices (EM 80, Beurer UK Ltd, Golborne, UK) were set up with the frequency of 20 Hz along with stimulation period of 1 second on and 1 second off throughout a 2 h oral glucose tolerance test (OGTT). The instruction for NMES intensity was that the maximal intensity participants were be able to withstand for 2 hours whilst imagining sitting at home watching TV without feeling discomfort. Prior to the OGTT, 5 min was given to identify the suitable intensity of stimulation and within the first 10 min of the OGTT participants were allowed to adjust the intensity once, after which, the intensity remained the same for the rest of OGTT. Participants were asked to sit in a chair with back, arms and legs supported during the stimulation. During trials, participants could watch TV, or read, but typing on a laptop or computer were avoided.
National Taiwan Normal University is the lead sponsor of 62 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Sitting
Behavioral: Sitting
Standing
Behavioral: Standing
Self-selected maximal intensity of neuromuscular electrical stimulation
Behavioral: Self-selected maximal intensity of neuromuscular electrical stimulation
Participants sat in a chair with back, arms and legs supported.
Participants were asked to stand with arms supported and feet spaced approximately 15 cm apart. If needed, adjustment of standing posture was allowed during standing trial to prevent orthostatic hypotension.
Small electrodes placed (5\*5 cm) on the lower limb of both legs. The instruction for NMES intensity was that the maximal intensity participants were be able to withstand for 2 hours whilst imagining sitting at home watching TV without feeling discomfort.
Changes in total energy expenditure during OGTT test.
Changes in total energy expenditure during OGTT test.
Time frame: 120 minutes
Changes in blood glycaemic responses during OGTT test.
Changes in blood glycaemic responses during OGTT test.
Time frame: 120 minutes
Changes in blood insulinaemic responses during OGTT test.
Changes in blood insulinaemic responses during OGTT test.
Time frame: 120 minutes
Changes in blood pressure during OGTT test.
Changes in blood pressure during OGTT test.
Time frame: 120 minutes
Changes in heart rate during OGTT test.
Changes in heart rate during OGTT test.
Time frame: 120 minutes
Changes in gut hormones (GLP-1, GIP & PYY etc.) responses during OGTT test.
Changes in gut hormones (GLP-1, GIP \& PYY etc.) responses during OGTT test.
Time frame: 120 minutes
Changes in total carbohydrate during OGTT test.
Changes in total carbohydrate during OGTT test.
Time frame: 120 minutes
Changes in total lipid oxidation during OGTT test.
Changes in total lipid oxidation during OGTT test.
Time frame: 120 minutes
This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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National Taiwan Normal University