An observational study in Endometrioma and Inflammation, sponsored by Muğla Sıtkı Koçman University. Completed at 1 site in Turkey. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-05-01.
Sponsored by Muğla Sıtkı Koçman University · Observational
Investigators aimed to measure the serum levels of adropin, salusin-α, netrin-1, and nesfatin-1, anti-inflammatory effects of which have been demonstrated previously, in endometriosis patients and to find out any association of them with insulin resistance.
Endometriosis is defined as the presence of endometrial gland and stroma outside the endometrial cavity affecting almost 10% of the women of reproductive age. Although benign, it disrupts the quality of life of the inflicted patients through symptoms such as dysmenorrhae, dyspareunia, chronic pelvic pain, and infertility. The pathogenesis of endometriosis has not yet been clearly elucidated, however, recent papers implies an underpinning role of inflammation There is a limited number of studies about the levels of these parameters in endometriosis and to date, no report is available on the levels of adropin and netrin-1 in endometriosis. Likewise, according to the investigator's literature search, no research explaining the association of endometriosis with insulin resistance has yet been published. In present study, in an attempt to describe inflammatory pathways playing a role in endometriosis pathogenesis, Investigators aimed to measure the levels of serum adropin, salusin-α, netrin-1, and nesfatin-1, anti-inflammatory effects of which have been priorly demonstrated, and to find out any association of them with insulin resistance.
901 studies on the registry are indexed under Endometriosis; 259 are open to participants now.
This study's enrollment of 48 is below the median of 128 across 344 observational studies indexed under Endometriosis.
Browse Endometriosis studies →Muğla Sıtkı Koçman University is the lead sponsor of 112 studies on the registry; 19 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Laporoscopically and histopathologically diagnosed 23 endometrioma patients and 25 healthy individuals with no endometrioma constituting the control group were included to this study.
·Histopathologically confirmed diagnosis of endometrioma
Exclusion Criteria:
Endometrioma (n=23)
Diagnostic Test: Adropin (ng/L)
Healthy controls Healthy volunteers n=25
Diagnostic Test: Adropin (ng/L)
Thawed samples were measured on a Molecular Devices SpectraMax i3 Multi-Mode, Microplate Reader (batch number: SER 35 370-1448, made in Austria) using enzyme linked immunosorbent assay (ELISA).
Also known as: Salusin-α (pg/mL), Netrin-1 (pg/mL), Nesfatin-1 (ng/mL)
Serum Adropin level
Serum Adropin level in ng/L
Time frame: preoperative in the morning or Day 1 in outpatient clinic,preprandial for healthy volunteers
Salusin-α
Serum Salusin-α level in pg/mL
Time frame: preoperative in the morning or Day 1 in outpatient clinic, preprandial for healthy volunteers
Netrin-1
Serum Netrin-1 level in pg/mL
Time frame: preoperative in the morning or Day 1 in outpatient clinic, preprandial for healthy volunteers
Nesfatin-1
Serum Nesfatin-1 level in ng/L
Time frame: preoperative in the morning or Day 1 in outpatient clinic, preprandial for healthy volunteers
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Muğla Sıtkı Koçman University