A Phase 4 interventional study of Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer) and triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip) in Pain, Joint Function Disorder and Inflammation, sponsored by Sohag University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-06-25.
Sponsored by Sohag University · Phase 4, Interventional, and Treatment
N=64 RA patients either early or established disease diagnosed after ACR/EULAR criteria 2010 with unilateral persistent knee arthritis. They were randomly assigned into two groups; group 1 received genicular nerve block, group 2 intra-articular triamcinolone. Both groups were examined by SOLAR scoring system, Visual analogue scale (VAS) and Lysholm score at 0, 2 and 12 weeks. A semi-quantitative score was used to assess tenderness and swelling at the same intervals.
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This study's enrollment of 64 is above the median of 50 across 2,437 interventional studies indexed under Inflammation.
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3 point genicular nerve block under ultrasound guidance. half ml of Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer) was injected in each point.
Drug: Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer) · Drug: triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip)
1 mL of triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip) was injected intraarticular.
Drug: Bupivacaine hydrochloride 0.5% (Marcaine, Pfizer) · Drug: triamcinolone 40 milligrams (Kenacort, Bristol Myers Squip)
3 point genicular nerve block
intra-articular injection of triamcinilone
Pain changes by VAS
0 means no pain and 10 means the most severe pain
Time frame: at 0 time after 2 weeks and after 12 weeks
SOLAR score for inflammation changes by ultrasound
0 means normal and 27 means the worst possible inflammation
Time frame: at 0 time after 2 weeks and after 12 weeks
Lysholm score for change in knee function
100 means the best performance and 0 means complete loss of function
Time frame: at 0 time after 2 weeks and after 12 weeks
This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
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Sohag University