An interventional study of MEPic in Airway Extubation, sponsored by Hospital Nacional Profesor Alejandro Posadas. Completed at 1 site in Argentina. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-05-04.
Sponsored by Hospital Nacional Profesor Alejandro Posadas · Not applicable, Interventional, and Diagnostic
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated. The maximum expiratory pressure measured in the usual way and the maximum expiratory pressure generated during the induced cough were taken as predictor variables. The outcome variable was extubation failure, measured at 72 hours and at 7 days.
After completing the spontaneous breathing trial (SBT), with the extubation decision defined by the physician in charge of the patient and maximal expiratory pressure (MEP) as usually measured greater than 30 centimeters of water (cmH2O). Following this, the patient was allowed to rest for 5 minutes in the same condition. With the patient in the supine position sitting 45 ° to 60 °, the closed suction catheter was removed, an elbow was placed at 90 ° and a bacterial filter in series with the endotracheal tube (ET), an adapter was also coupled with a outlet port to the aneroid pressure gauge. In series an inspiratory unidirectional valve was placed that did not allow expiration. Immediately 2 ml of physiological solution was slowly instilled through the port in the 90º elbow to trigger the cough reflex. The presence or absence of reflex cough and the MEP during induced cough (MEPic) value were verified.
As a safety method, the procedures were stopped if the patient presented signs of intolerance such as respiratory rate (RF)> 35 breaths per minute, saturation \<90%, heart rate (HR)> 140 beats per minute or increase of 20 % of resting levels.
346 studies on the registry are indexed under Cough; 71 are open to participants now.
This study's enrollment of 80 is above the median of 70 across 263 interventional studies indexed under Cough.
Browse Cough studies →Hospital Nacional Profesor Alejandro Posadas is the lead sponsor of 8 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
* Ready for extubation (pass SBT) * Measurement of maximum expiratory pressure during the induced cough (MEPic)
Diagnostic Test: MEPic
* patient in the supine position sitting 45° to 60°, * closed suction catheter was removed * a 90° elbow was placed and a bacterial filter in series with endotracheal tube * adapter was also coupled to the aneroid pressure gauge * in series an inspiratory unidirectional valve was placed that did not allow expiration * 2 ml of physiological solution was slowly instilled through the port in the 90º elbow to cause induced cough
Extubation failure
Endotracheal tube removal failure
Time frame: 72 hours
Extubation failure
Endotracheal tube removal failure
Time frame: 7 days
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Hospital Nacional Profesor Alejandro Posadas