CClinicalTrials.gg
CompletedNCT04355013Updated May 7, 2025Results posted

Temperature Monitoring in Cardiac Surgery: Agreement Between Different Clinical Methods

An observational study in Temperature Change, Body, sponsored by Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León. Completed at 1 site in Spain. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2025-05-07.

Sponsored by Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León · Observational

Study type
Observational
Model
Case-crossover
Time perspective
Prospective
Enrollment
48
Ages
18 Years to 90 Years
Sex
All
01

Study summary

Observational study to compare core temperatures obtained by 6 methods in patients undergoing cardiac surgery under cardiopulmonary bypass.

Read the detailed description

This study compares the core temperatures obtained by means of different probes placed in nasopharinx, pulmonary artery, arterial outlet, venous inlet, bladder and forehead in patients undergoing cardiac surgery under cardiopulmonary bypass.

02

Conditions studied

  • Temperature Change, Body

Keywords

  • Core temperature
  • Cardiac surgery
03

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients undergoing cardiac surgery under cardiovascular bypass

Inclusion criteria

  • Only patients requiring a pulmonary artery catheter were included.

Exclusion criteria

Exclusion Criteria:

  • Sepsis or previous fever.
  • Previous bladder catheter without termistor
  • Deep hypothermic circulatory arrest.
04

Study design

Observational model
Case-crossover
Time perspective
Prospective
Enrollment
48 participants (actual)
Patient registry
No

Interventions

  • DeviceCore emperature monitoring

    Monitoring core temperatures with probes placed in the arterial outlet and venous inlet of extracorporeal pump, pulmonary artery, bladder, nasopharinx and forehead using a doublé-sensor probe

05

What researchers measure

Primary outcomes

  1. Agreement Between Different Core Temperature Methods

    Agreement between core temperatures obtained in arterial CPB output versus venous inlet of CPB, bladder, pulmonary artery, nasopharynx and forehead (Tcore). The measurements were compared between the different methods using the Bland-Altman method of repeated measures and expressed as mean difference (reference method-alternative method) plus CI95%.

    Time frame: 24 temperature measures per patient recorded at 5-min intervals for each method and averaged using the Bland-Altman method for repeated measures

06

Results

Posted Oct 17, 2024

Participant flow

Adult patients undergoing cardiac surgery using cardiopulmonary bypass and requiring hemodynamic monitoring by means of a pulmonary artery catheter.

Participant flow — Overall Study
MilestonePatients Undergoing CPB Cardiac Surgery.
Started48
Completed48
Not completed0

Outcome measures

PrimaryAgreement Between Different Core Temperature Methods

Agreement between core temperatures obtained in arterial CPB output versus venous inlet of CPB, bladder, pulmonary artery, nasopharynx and forehead (Tcore). The measurements were compared between the different methods using the Bland-Altman method of repeated measures and expressed as mean difference (reference method-alternative method) plus CI95%.

Time frame:
24 temperature measures per patient recorded at 5-min intervals for each method and averaged using the Bland-Altman method for repeated measures
Reported as:
Median · celsius degrees (mean difference)
Agreement Between Different Core Temperature Methods
celsius degrees (mean difference)Arterial OutletNasopharyngealBladderTcoreVenous Inflow
Agreement Between Different Core Temperature Methods35.0 (34.9 to 35.0)35.2 (35.1 to 35.3)35.6 (35.5 to 35.6)34.8 (34.7 to 35.0)34.8 (34.7 to 34.9)
Statistical analysis
  • Arterial Outlet vs Nasopharyngeal · Bland-altman for repeated measures: -0.16 · 95% CI -1.10 to 0.77
  • Arterial Outlet vs Venous Inflow · Bland-Altman · Mean difference (final values): 0.16 · 95% CI -0.63 to 0.95
  • Arterial Outlet vs Bladder · Bland-Altman · Mean difference (final values): -0.62 · 95% CI -1.98 to 0.74
  • Arterial Outlet vs Tcore · Bland-Altman · Mean difference (final values): 0.08 · 95% CI -1.38 to 1.54
  • Nasopharyngeal vs Venous Inflow · Mean difference (final values): 0.32 · 95% CI -0.73 to 1.38
  • Nasopharyngeal vs Bladder · Mean difference (final values): -0.46 · 95% CI -1.50 to 0.59
  • Nasopharyngeal vs Tcore · Bland-altman for repeated measures: 0.24 · 95% CI -0.90 to 1.39

Adverse events

Collected over No adverse effects were measured. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
No Adverse Effects Were Measured———

Baseline characteristics

Age, Continuous
Age, Continuous(years)Patients Undergoing CPB Cardiac Surgery.
Median66 (60 to 76)
Sex: Female, Male
Sex: Female, Male(Participants)Patients Undergoing CPB Cardiac Surgery.
Female17
Male31
Race (NIH/OMB)
Race (NIH/OMB)(Participants)Patients Undergoing CPB Cardiac Surgery.
American Indian or Alaska Native0
Asian0
Native Hawaiian or Other Pacific Islander0
Black or African American0
White48
More than one race0
Unknown or Not Reported0
Race and Ethnicity Not Collected
Race and Ethnicity Not Collected(Participants)Patients Undergoing CPB Cardiac Surgery.
Weight
Weight(kilograms)Patients Undergoing CPB Cardiac Surgery.
Median70 (64 to 82)
Height
Height(centimeters)Patients Undergoing CPB Cardiac Surgery.
Median165 (160 to 170)
07

Study locations

1 site
  • IBSAL
    Salamanca, 37007, Spain
08

References and documents

Publications

  • Sastre JA, Lopez T, Moreno-Rodriguez MA, Reta-Ajo L, Rubia-Martin MC, Diez-Castro R. Reliability of different body temperature measurement sites during normothermic cardiac surgery. Perfusion. 2023 Apr;38(3):580-590. doi: 10.1177/02676591211069918. Epub 2022 Feb 8. PubMed 35133212 ↗

Study documents

  • Protocol and statistical analysis plan · Apr 27, 2016

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

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Registry details

Key details

Study ID
NCT04355013
Lead sponsor
Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Responsible party
Jose Alfonso Sastre (Principal investigator, Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León) — Principal investigator
First posted
Apr 21, 2020
Start date
Sep 28, 2016
Primary completion
Nov 22, 2017
Completion
Nov 22, 2017
Results posted
Oct 17, 2024
Last update
May 7, 2025

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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