ClinicalTrials.gg
CompletedNCT04340570Updated Jan 8, 2026

Effect of Medication Management at Home Via Pharmacy Home Televisits

An interventional study of Medication management via televisit to home in Polypharmacy, Deprescribing and Telemedicine, sponsored by VA Office of Research and Development. Completed at 2 sites in United States. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-08.

Sponsored by VA Office of Research and Development · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
304
Allocation
Randomized
Ages
65 Years and older
Sex
All
01

Study summary

Older Veterans, particularly those with multiple chronic conditions requiring complex medication regimens, are more susceptible to adverse effects of medications. In this study, the investigators will examine the effect of a pharmacist led medication management intervention delivered by home televisit on improving medication use. The investigators anticipate that televisit to home by pharmacist for medication management may enhance use of medications at home by Veterans particularly those with complex medication regimens.

Read the detailed description

Older adults are more likely to suffer from multiple chronic conditions, to be prescribed multiple medications, and are more susceptible to adverse effects of medications. In addition, older adults often use over-the-counter medications and supplements, further complicating their medication regimen. Complex medication regimens are potentially harmful to older adults due to potential drug interactions, potentially inappropriate prescribing or over-the-counter drug use, and medication non-adherence that may lead to poor control of chronic disease. Interventions aimed at reducing medication discrepancy in the ambulatory clinic setting, such as the review of written medication lists, and implementation of "brown bag" reconciliation (asking patients to bring in all medication bottles for review in the clinic) continues to be challenging and have limited success. Clinical pharmacist led interventions to improve appropriate medication use in older adults, including the application of the START/STOPP criteria, have demonstrated effectiveness in reducing adverse drug events. With the increased capability of VA telemedicine to reach Veteran in their homes, delivering medication management via televisit by clinical pharmacists has the potential to yield similar benefits for a larger number of older Veterans.

Telemedicine is an increasingly vital component within VHA to increase access and improve quality of care. By extending care beyond brick-and-mortar clinics, telemedicine increases the reach of care teams and is more convenient for patients, resulting in improved patient satisfaction. Using the capability of telemedicine to reach patients' homes, the investigators propose to examine the effect of medication management by clinical pharmacists via home video televisits, as home video visits have the potential to provide direct visualization of medications in older adults' homes, thereby reducing medication discrepancy and increasing medication adherence. Pharmacist management for older adult medication regimen may also improve appropriate medication use in older adults through direct pharmacist-patient interview and education. In support of this application, preliminary data from the team of investigators demonstrate acceptability of video televisits by older adults, that there is good uptake by patients and VA providers, and that video televisits into the home are feasible.

In this study, the investigators aim to develop a protocol for pharmacy home televisits for medication management in older adults who have multiple chronic conditions and are on multiple medications. The investigators will then conduct a randomized trial to examine the effect of these televisits on appropriate medication use, medication discrepancies, adherence and adverse drug events. The investigators anticipate that a pharmacist led medication management home televisit intervention will lead to reduction in potentially inappropriate use of medication, reduction in medication discrepancies, increased medication adherence and reduced adverse drug events in older adults compared to older adults receiving usual care. The investigators will also examine the potential challenges in implementing the intervention so that the study findings may inform future implementation.

02

Conditions studied

  • Polypharmacy
  • Deprescribing
  • Telemedicine

Keywords

  • polypharmacy
  • deprescribing
  • multiple chronic diseases
03

In context

Multiple Chronic Conditions

89 studies on the registry are indexed under Multiple Chronic Conditions; 16 are open to participants now.

This study's enrollment of 304 is above the median of 128 across 71 interventional studies indexed under Multiple Chronic Conditions.

Browse Multiple Chronic Conditions studies →

Lead sponsor

VA Office of Research and Development is the lead sponsor of 1,771 studies on the registry; 392 are open to participants now.

Of its 213 completed or terminated interventional studies of FDA-regulated products, 185 (87%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Had at least 1 VA primary care visit within past year
  • At least 2 chronic conditions
  • At least 5 daily medications

Exclusion criteria

Exclusion Criteria:

  • Dementia diagnosis
  • Lacks capacity for
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

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05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
304 participants (actual)

Study arms

  • Experimental
    Intervention

    Receives pharmacist home televisit for medication management

    Behavioral: Medication management via televisit to home

  • No intervention
    Usual Care

    Usual care for outpatient medication management

Interventions

  • BehavioralMedication management via televisit to home

    Pharmacist led home based televisit for medication management

06

What researchers measure

Primary outcomes

  1. Proportion of subjects with Potentially inappropriate medication use

    Potentially inappropriate medication use (PIM) assessed by blinded reviewer.

    Time frame: 6 months

Secondary outcomes

  1. Medication Appropriateness

    Measured using Medication Appropriateness Index

    Time frame: 6 months

  2. Adverse drug events

    Assessed from subject survey and chart review and rated as preventable vs. nonpreventable

    Time frame: 6 months

  3. Medication self efficacy

    Measured using patient reported "Medication Understanding Use and Self-Efficacy Scale"

    Time frame: 6 months

07

Study locations

2 sites
  • VA Bedford HealthCare System, Bedford, MA
    Bedford, Massachusetts 01730-1114, United States
  • James J. Peters VA Medical Center, Bronx, NY
    The Bronx, New York 10468-3904, United States
08

References and documents

Publications

  • Hawley CE, Wagner C, Venegas MD, Genovese N, Triantafylidis LK, McCullough MB, Beizer JL, Hung WW, Moo LR. Connecting the disconnected: Leveraging an in-home team member for video visits for older adults. J Am Geriatr Soc. 2024 May;72(5):1408-1419. doi: 10.1111/jgs.18663. Epub 2023 Nov 13. PubMed 37960887 ↗
  • Hossain SR, Samant AN, Balsamo BC, Hawley CE, Zanchelli MC, Zhu C, Venegas MD, Robertson M, McCullough MB, Beizer JL, Boockvar KS, Siu AL, Moo LR, Hung WW. Effect of Medication Management at Home via Pharmacist-Led Home Televisits: Protocol for a Cluster Randomized Controlled Trial. JMIR Res Protoc. 2025 Feb 5;14:e65141. doi: 10.2196/65141. PubMed 39908544 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04340570
Responsible party
Sponsor
First posted
Apr 9, 2020
Start date
Jul 16, 2020
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025
Last update
Jan 8, 2026

Study contacts

William W Hung, MD AB MPH
principal investigator · James J. Peters Veterans Affairs Medical Center
Lauren Rachel Moo, MD
principal investigator · VA Bedford HealthCare System, Bedford, MA

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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