An interventional study of PRISM Arm and Enhanced Usual Care Arm in Medication Adherence, sponsored by Brigham and Women's Hospital. Not yet recruiting at 1 site in United States. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Brigham and Women's Hospital · Not applicable, Interventional, and Health services research
The objective of this study is to test a multidisciplinary care team behavioral intervention to enhance medication adherence among older adults with multiple chronic conditions (MCC). The Personalized Routine and Habit Integration to Support Medication Management (PRISM) intervention is a novel, scalable intervention delivered by pharmacists and occupational therapists (OTs) that aims to improve medication adherence by reducing regimen complexity and solidifying medication habits within daily routines. The goal of this randomized control trial is to evaluate the effectiveness and implementation of PRISM compared with enhanced usual care.
937 studies on the registry are indexed under Medication Adherence; 159 are open to participants now.
This study's planned enrollment of 100 is below the median of 120 across 768 interventional studies indexed under Medication Adherence.
Browse Medication Adherence studies →Brigham and Women's Hospital is the lead sponsor of 1,267 studies on the registry; 228 are open to participants now.
Of its 116 completed or terminated interventional studies of FDA-regulated products, 65 (56%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
The PRISM arm will receive three sessions: 1) comprehensive medication management session with a clinical pharmacist, 2) an in-home visit with an occupational therapist (OT), and then 3) follow up phone call with OT.
Behavioral: PRISM Arm
The EUC arm will receive a comprehensive medication management session with a clinical pharmacist.
Behavioral: Enhanced Usual Care Arm
The PRISM arm will receive three sessions: 1) comprehensive medication management session with a clinical pharmacist, 2) an in-home visit with an occupational therapist (OT), and then 3) follow up phone call with OT.
The EUC arm will receive a comprehensive medication management session with a clinical pharmacist.
PDC (Continuous) - Cardiometabolic
Medication adherence to cardio-metabolic pill-form daily medications including the following classes: ACE inhibitor, Angiotensin Receptor Blockers (ARBs), Beta-Blockers, Calcium Channel Blockers, Diuretics, Lipid-lowering, Metformin
Time frame: Through 6-months post-baseline
PDC (Continuous) - All
Medication adherence to all daily prescription pill-form medications
Time frame: Through 6-months post-baseline
PDC (Continuous) - Study-entering
Medication adherence to study-entering medication i.e. the medciation that was identified during the eligibility screening process as having poor medication adherence.
Time frame: Through 6-months post-baseline
Medication Adherence Report Scale 10-item (MARS-10)
Self reported; medication ahderence to all prescriptoin daily medications
Time frame: Through 3-months post-baseline
Regimen Knowledge (continuous)
Participant knowledge of prescribed medications, including their purpose, dosage, and administration instructions using Medication Purpose \& Dosage Identification Score (MPDS).
Time frame: Through 3-months post-baseline
Regimen Complexity (continuous)
Complexity of the participant's prescribed medication regime using Medication Regimen Complexity Index (MRCI).
Time frame: Through 3-months post-baseline
Daily Routine (continuous)
Daily activity patterns and routines, including the timing of activities throughout the day using a time diary.
Time frame: Through 3-months post-baseline
Medication Habits (continuous)
The extent to which medication-taking is performed automatically as a habitual behavior using Self-Report Behavioral Automaticity Index (SRBAI).
Time frame: Through 3-months post-baseline
Problem Solving Skills (continuous)
Participant ability to identify, address, and learn from problems affecting medication-taking and health management using Health Problem-Solving Scale (HPSS).
Time frame: Through 3-months post-baseline
Start is estimated for Feb 2027; primary completion for Feb 2028, 12 months later.
Of 425 non-industry interventional studies with no phase under Medication Adherence, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 42. This study's planned 12 months is below that.
Counting every sponsor, half of 442 studies reached it within 21 months; a quarter within 11 and three quarters within 41.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Brigham and Women's Hospital →