An observational study in Emphysematous Pyelonephritis, sponsored by Hospital Universitario Dr. Jose E. Gonzalez. Status unknown at 1 site in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-04-01.
Sponsored by Hospital Universitario Dr. Jose E. Gonzalez · Observational
Emphysematous pyelonephritis is a lifethreatening necrotizing infection of the kidney characterized by accumulation of gas in the renal parenchyma and within the surrounding tissues. The aim of the study is to report the outcome of the management of this condition at the investigators institution and to determine the microbiological characteristics, antibiotic resistance patterns, and to analyze factors predicting mortality and intensive care unit admission.
The investigators are planning to perform a retrospective study analyzing cases of emphysematous pyelonephritis from a single tertiary care institution in the north of Mexico in the period of 2011-2021. The diagnosis of emphysematous pyelonephritis is confirmed by computed tomography. Demographic, clinical, biochemical, therapeutic management, and outcomes will be collected. Variables will be analyzed to determine factors associated with admission to intensive care unit and mortality. Urine cultures will be analyzed and drug resistance profile will be determined using microdilution plate. Clinical and demographic characteristics will be analyzed using Chi square test for categorical variables, and T-test for numerical variables. Statistical significance is set at p\<0.05. Statistical analysis will be performed with the SPSS software version 20.0.
Patients with a confirmatory diagnosis using emphysematous pyelonephritis by computed tomography are included, as well as signs and symptoms of upper urinary tract infection and data of systemic inflammatory response. Participants are usually admitted to the emergency room and recruited for analysis during hospitalization.
Exclusion Criteria:
This is a single-group cohort study. A sub-classification will be used in order to differentiate patients that did not require intensive care, the ones who admitted to intensive care and mortality.
Procedure: Nephrectomy
Different therapeutic options are described in literature for emphysematous pyelonephritis. In our center, medical treatment (no invasive procedure), ureteral stent (endourologic procedure), percutaneous drainage (minimally invasive procedure), and nephrectomy are the therapeutic options for this disease.
Also known as: ureteral stent, percutaneous drainage, medical treatment
Number of patients with admission to Intensive care unit
Patients with criteria to admit to intensive care unit
Time frame: 10 years
Rate of mortality
Death cases during hospitalization
Time frame: 10 years
Antibiotic susceptibility
Drug resistance profile will be determined using microdilution plate.
Time frame: 10 years
Plan to share: Yes — An e-mail contact of the research party will be published in order to share information of our data, excel databases and other type of information.
Supporting information: Study protocol, Sap
This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Hospital Universitario Dr. Jose E. Gonzalez