CClinicalTrials.gg
Status unknownNCT04301674Updated Aug 24, 2022

Metabolomics in Occupational Asthma

An observational study in Asthma, Occupational, sponsored by Oslo University Hospital. Status unknown at 1 site in Norway. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-08-24.

Sponsored by Oslo University Hospital · Observational

The sponsor has not verified this record recently (last verified Aug 2022), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
80
Ages
18 Years and older
Sex
All
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Study summary

The project aims to increase the diagnostic accuracy in occupational asthma (OA), with emphasis on Irritant Induced Asthma (IIA). Currently, most patients are evaluated in occupational medicine by comparing the exposure and symptom characteristics with epidemiological data. Biological markers may be present in AA, but presently not in IIA. The majority of cases evaluated are considered as possible IIA, i.e. low-dose multiple exposures. VOC features will be analyzed with the Breath Biopsy® and TD-GS-MS (Owlstone Medical Ltd, UK).

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Conditions studied

  • Asthma, Occupational

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03

In context

Asthma

3,921 studies on the registry are indexed under Asthma; 507 are open to participants now.

This study's planned enrollment of 80 is below the median of 150 across 970 observational studies indexed under Asthma.

Browse Asthma studies →

Lead sponsor

Oslo University Hospital is the lead sponsor of 810 studies on the registry; 148 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Patients with occupational asthma, referred to the Unit of Environmental and Occupational medicine OUS for evaluation of OA.and healthy volunteers

Inclusion criteria

  • capable of informed consent.
  • asthma diagnosis established by lung specialist or healthy control.

Exclusion criteria

Exclusion Criteria:

  • skin allergy towards plastics or rubber.
  • immunocompromised by oral medication.
  • contagious respiratory disease.
  • biopsy of lung parenchyma within the last 36 hours.
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
80 participants (estimated)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Occupational Asthma

    Patients refered for assesment of occupational asthma

    Device: Breath Biopsy

  • Respiratory Healthy Control

    Employees at Oslo University Hospital

    Device: Breath Biopsy

Interventions

  • DeviceBreath Biopsy

    ReCIVA breath sampler (Owlstone Medical, Cambridge, UK)

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What researchers measure

Primary outcomes

  1. Discovery of VOC Biomarkers in Asthma

    To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify asthma.

    Time frame: Baseline

  2. Discovery of VOC Biomarkers in Occupational Irritant Asthma

    To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify irritant asthma after occupational exposures.

    Time frame: Baseline

07

Study locations

1 of 1 sites recruiting
  • Oslo University Hospital
    Oslo, Norway
    Recruiting
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 24, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04301674
Lead sponsor
Oslo University Hospital
Collaborators
Owlstone Ltd
Responsible party
Bato Hammarstrøm (Senior consultant/Research group leader, Oslo University Hospital) — Principal investigator
First posted
Mar 10, 2020
Start date
Oct 15, 2021
Primary completion
Dec 31, 2022 (estimated)
Completion
Jun 1, 2023 (estimated)
Last update
Aug 24, 2022

Study contacts

Bato Hammarström, MD/PhD
Contact
bato.hammarstrom@ous-hf.no
+47 230 16667
Tonje Trulssen Hildre, M.Sc.
Contact
tohild@ous-hf.no
Bato Hammarstrøm, MD/PhD
principal investigator · Oslo University Hospital
Tonje Trulssen Hildre, M.Sc.
study chair · Oslo University Hospital
Hilde Heiro, MD
study chair · Oslo University Hospital
Britt G Randem, MD/PhD
study chair · Oslo University Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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