An observational study in Cardiogenic Shock, sponsored by Niguarda Hospital. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-14.
Sponsored by Niguarda Hospital · Observational
The study will provide data on profile, management, outcome, and evolution over time of cardiogenic shock patients admitted to the Intensive Coronary Care Units
Cardiogenic shock (CS) is the most severe form of acute heart failure. Data on epidemiology of CS have been drawn from previously published registries focussing on acute coronary syndrome (ACS) and myocardial infarction (AMI). Indeed, CS occurs in 5-7% of patients presenting with ACS and ACS has been reported as the most prevalent cause of CS, accounting for about 80% of cases.
However, recent evidences in a contemporary cohort in North America have shown that more than two-thirds of all cardiogenic shock cases were related to causes other than AMI and that these patients had outcomes at least as poor as patients with AMI-CS.
Given the high short-term mortality of these patients and the need for developing dedicated cardiac shock centres and systems of care to time our interventions, it is of utmost importance to achieve a better clinical phenotyping of the heterogeneous causes and presentations of CS patients and carefully perform research outcome.
Accordingly, the Altshock-2 registry will represent a unique opportunity to evaluate the full spectrum of CS admitted in Intensive Coronary Care Units and to collect a selected number of variables related to aetiology, clinical presentation, ongoing pharmacological treatments, use of mechanical support devices and outcome.
296 studies on the registry are indexed under Shock, Cardiogenic; 134 are open to participants now.
This study's planned enrollment of 3,000 is above the median of 200 across 155 observational studies indexed under Shock, Cardiogenic.
Browse Shock, Cardiogenic studies →Niguarda Hospital is the lead sponsor of 68 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All-comers cardiogenic shock patients admitted to the Intensive Coronary Care Units
All consecutive CS patients hospitalized in the above reported centres between January 2020 and December 2030.
Cardiogenic shock is defined as:
All-comers cardiogenic shock patients Admitted to the Intensive Coronary Care Units
To provide data on profile, management, outcome, and evolution over time of CS patients admitted to ICCU
No formal sample size calculation was used to manage enrolment in the registry since the goal is to obtain participation by all possible eligible patients. No formal pre-specified hypothesis testing is planned. All analyses will be descriptive in nature Accordingly, measures of primary outcome will not be provided
Time frame: 10 years
Re-hospitalization
Number of patients
Time frame: 10 years
To collect data on clinical characteristics and management of cardiogenic shock patients
Accordingly to the descriptive nature of the analyses, measures of secondary outcome will not be provided
Time frame: 10 years
Plan to share: Undecided
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Niguarda Hospital