An observational study in Oral Lichen Planus, sponsored by University of Birmingham. Completed at 1 site in United Kingdom. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2024-04-18.
Sponsored by University of Birmingham · Observational
The principal research objective is to provide enhanced understanding of the cellular and molecular events important in the pathogenesis of Oral Lichen Planus to enable improved diagnosis and development of novel treatments for patients.
The following questions will also be addressed:
143 studies on the registry are indexed under Lichen Planus, Oral; 25 are open to participants now.
This study's enrollment of 70 is close to the median of 75 across 38 observational studies indexed under Lichen Planus, Oral.
Browse Lichen Planus, Oral studies →University of Birmingham is the lead sponsor of 182 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients registered at Birmingham Dental Hospital and attending a clinic for OLP diagnosis.
Patients will be identified by their normal healthcare consultant and invited to participate.
Informed consent will always be obtained prior to any study related procedures being undertaken.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Histological architecture
Are the histological architectural tissue changes that take place in oral lichen planus quantifiable using computer based imaging, graph theory and fractal geometry principles?
Time frame: Through study completion, (maximum 12 months from the defined end of study)
Comparisons with other dysplastic lesions
What is the nature of such architectural changes and what are the differences with normal, dysplastic and neoplastic epithelia
Time frame: Through study completion, (maximum 12 months from the defined end of study)
Statistical classifications
Is it possible to produce evidence-based statistical classification into established diagnostic classes using the proposed methodology
Time frame: Through study completion, (maximum 12 months from the defined end of study)
Automation of morphological features
Is it possible to automate such morphometrical analysis/classification?
Time frame: Through study completion, (maximum 12 months from the defined end of study)
Molecular expression of Oral Lichen Planus markers
Is it possible to determine differences in genetics and gene expression of keratinocytes involved in Oral Lichen Planus compared to those of 'normal' tissue by using biopsy material and an in vitro model of oral lichen planus?
Time frame: Through study completion, (maximum 12 months from the defined end of study)
Plan to share: No
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This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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