An interventional study of Platelet rich fibrin in Gingival Recession, sponsored by Universidad Antonio Nariño. Completed at 1 site in Colombia. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-01-30.
Sponsored by Universidad Antonio Nariño · Not applicable, Interventional, and Treatment
Several surgical techniques and various adjunctive agents have been used to covered Gingival Recession (GR) and promote clinical outcomes. The treatment of the GR more used (gold standard) is the root coverage with surgical procedures and connective tissue graft, but it has limitations due to the conditions of the donor graft. Is necessary develop other biomaterials for these cases.
The platelet rich fibrin is a autologous biomaterial that has gained tremendous momentum having been utilized for a variety of dental and medical procedures including periodontal surgeries. However, results remain contradictory and mainly focus on the hard and soft tissue healing, aesthetics and postoperative discomfort.
The objective of this study was to evaluate the clinical effects of coronal advanced flap (CAF) and CAF + Platelet Rich Fibrin (PRF) on Root coverage (RC) over a period of 24 month.
Exclusion Criteria:
Roots covered with coronally advanced flap (CAF) and platelet rich fibrin (PRF) (CAF+PRF)
Other: Platelet rich fibrin
Roots covered with coronally advanced flap (CAR)
Other: Platelet rich fibrin
The roots of patients with diagnosis of gingival recessions will be covered with coronally advanced flap (CAF) and platelet rich fibrin (PRF) (CAF+PRF)
Change of percentage of root coverage (PRC) from baseline at 12 and 24 months
Complete root coverage after surgical correction measured in percentage by using periodontal probe. PRC= Preoperative recession depth - Postoperative recession depth X 100 % Preoperative recession depth
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Vertical gingival recession (VGR)
It is measuring the distance from the cemento-enamel junction (CEJ) to the margin of the gingiva at the midbuccal point of the teeth (measured using a periodontal probe in millimeters).
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Horizontal gingival recession (HGR)
Measured horizontally between two borders of the recession. (measured using a periodontal probe in millimeters).
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Probing depth (PD)
It is measuring the distance from the gingival margin to the base of the pocket using periodontal probe. The probe will be inserted parallel to the long axis of the tooth using light force. (measured using a periodontal probe in millimeters).
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Clinical attachment level(CAL)
Two measurements will be used to calculate the CAL: the probing depth and the distance from the gingival margin to the CEJ.
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Gingival tissue thickness
The gingiva mid-buccally in the attached gingiva will be penetrated with an endodontic reamer with a silicon disc stop. The measure of penetration will be measured with dentimeter (mm).
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Keratinized tissue height (KTH)
To measure the tissue thickness, a guiding device will be made to standardize the region to be measured and then, at a specific point, the mucosa will be punctured with an endodontic spacer and the thickness marked with a rubber marker. Then, using a digital caliper, the thickness will be measured.
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Gingival bleeding index (IS)
Evaluation of the presence and absence of bleeding in the gingival margin through the gingival sulcus. The index is calculated after penetration of the sulcus by the periodontal probe, bleeding surfaces are noted and then counted. The index is calculated by dividing the number of surfaces that bleed by the total number of teeth and then multiplying by 100 to reach the percentage of bleeding index.
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Visual analog scale (VAS)
Visual analog scale
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Evaluation of oral health impact on quality of life, using the Oral Health Impact Profile (OHIP-14) questionnaire.
Evaluate the impact of oral health on patient's quality of life before and 1 year after implant installation. This evaluation will be carried out through the application of a questionnaire with 14 questions (Oral Health Impact Profile: OHIP-14) that assess the patient's perception regarding the impact of oral conditions on their well-being
Time frame: baseline, 1, 3 , 6, 9, 12 and 24 months
Plan to share: No
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Universidad Antonio Nariño