An interventional study of Ropivacaine in Laparoscopic Gastrectomy, sponsored by Keimyung University Dongsan Medical Center. Status unknown. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2020-01-30.
Sponsored by Keimyung University Dongsan Medical Center · Not applicable, Interventional, and Prevention
Investigators want to find the concentration of epidural ropivacaine, which can block hemodynamic changes in the onset of pneumoperitoneum in the laparoscopic gastrectomy.
According to previous patient's response, the investigators will allocate the concentration of ropivacaine of next patient during Co2 insufflation. And, for this allocation of concentration of ropivacaine, the investigators use biased coin design up-and-down method.
Based on the practices, the starting concentration is 0.375 %, and the step size of concentration is 0.125%.
149 studies on the registry are indexed under Pneumoperitoneum; 29 are open to participants now.
This study's planned enrollment of 50 is below the median of 79 across 96 interventional studies indexed under Pneumoperitoneum.
Browse Pneumoperitoneum studies →Keimyung University Dongsan Medical Center is the lead sponsor of 81 studies on the registry; 10 are open to participants now.
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Drug: Ropivacaine
According to previous patient's response, the investigators will allocate the concentration of ropivacaine of next patient during Co2 insufflation. And, for this allocation of concentration of ropivacaine the investigators use biased coin design up-and-down method.
Changes from baseline in heart rate (bpm) after CO2 insufflation
Heart rate will be recorded before anesthesia induction, during CO2 insufflation, after Co2 insufflation. The mean value of heart rate before anesthesia induction will be regarded as the baseline values. If maximum heart rate after Co2 insufflation increased by \>20% from baseline value, the response will be regarded as "fail" and increased concentration of ropivacaine will be applied to next patient by up and down method.
Time frame: immediately after CO2 insufflation : 1,2,3,4,5,6, 7, 8, 9, 10 minutes after CO2 insufflation
Changes from baseline in mean arterial pressure (mmHg) after CO2
Mean arterial pressure will be recorded before anesthesia induction, during CO2 insufflation, after Co2 insufflation. The mean value of mean arterial pressure before anesthesia induction will be regarded as the baseline values. If maximum mean arterial pressure after Co2 insufflation increased by \>20% from baseline value, the response will be regarded as "fail" and increased concentration of ropivacaine will be applied to next patient by up and down method.
Time frame: immediately after CO2 insufflation : 1,2,3,4,5,6, 7, 8, 9, 10 minutes after CO2 insufflation
No study locations are listed for this record.
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Keimyung University Dongsan Medical Center