An interventional study of FFR in Myocardial Ischemia, sponsored by The People's Hospital of Liaoning Province. Status unknown at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2020-01-13.
Sponsored by The People's Hospital of Liaoning Province · Not applicable, Interventional, and Diagnostic
To study the effect of myocardial microcirculation disturbance on coronary flow reserve fraction, compare the evaluation value of IMR, FFR and QCA on myocardial ischemia, and discuss the correlation among them.
In this study, 60 patients with critical lesions indicated by coronary angiography will be admitted. The investigators collected the basic clinical data (gender, age, body mass index, smoking history, hypertension, diabetes, hyperlipidemia), laboratory data (creatinine, cholesterol, triglycerides) and measured their FFR and IMR.
3,233 studies on the registry are indexed under Myocardial Ischemia; 396 are open to participants now.
This study's planned enrollment of 60 is below the median of 120 across 1,895 interventional studies indexed under Myocardial Ischemia.
Browse Myocardial Ischemia studies →The People's Hospital of Liaoning Province is the lead sponsor of 2 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:(1) Age: 18-75 years old, unlimited for men and women;
(2) Quantitative coronary angiography (QCA) showed that there was a critical lesion in the proximal or middle segment of the coronary artery (diameter stenosis rate was 50% - 70%), and the diameter of the artery was more than 2.5mm;
(3) Agree to participate in the study and sign informed consent
-
Exclusion Criteria:(1) Patients with acute myocardial infarction within one month;
(2) Patients with congenital heart disease, severe valve disease, dilated cardiomyopathy, pulmonary heart disease and hypertrophic cardiomyopathy;
(3) With severe heart failure (NYHA cardiac function grade ≥ grade III or left ventricular ejection fraction \< 35%);
(4) Patients with less than 1 year of stent implantation or with coronary artery bypass grafting;
(5) Patients with left main lesion, severe distorted calcification, open lesion, bifurcated lesion or complete occlusion;
(6) Patients with severe hepatorenal insufficiency;
(7) Contraindications to adenosine, aspirin and clopidogrel;
(8) Patients with advanced tumor or life expectancy less than 1 year;
(9) Patients with severe asthma or uncontrolled asthma;
(10) Women in pregnancy.
-
Quantitative coronary angiography (QCA) showed that there was a critical lesion in the proximal or middle segment of the coronary artery (diameter stenosis rate was 50% - 70%), and the diameter of the artery was more than 2.5mm
Combination Product: FFR
FFR measurement: Pressure guid wire(radianalyzer Xpress 12711) is produced in Switzerland. After the pressure of the aorta and the pressure guide wire is balanced, Send the pressure guide wire to the distal part of the lesion(more than 20 mm away from the lesion) . Adenosine is injected into the vein,then,record the FFR index 3 times and take the average value as the final measurement index.
IMR
Resistance index of microcirculation
Time frame: one hour
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
The People's Hospital of Liaoning Province