An observational study in Critical Illness, sponsored by Intensive Care National Audit & Research Centre. Status unknown at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-10-05.
Sponsored by Intensive Care National Audit & Research Centre · Observational
CIRCA aims to determine the incidence and outcomes of in-hospital cardiac arrest (IHCA) in UK intensive care units (ICUs) and explore associated risk factors with ICU and hospital survival and quality of survival following hospital discharge.
Cardiac arrest is often categorised by location, out-of-hospital or in-hospital (IHCA), as there are important differences in population characteristics and aetiology. The National Cardiac Arrest Audit (NCAA) was established to audit resuscitation teams in response to IHCA, and collects information about patient characteristics, resuscitation processes, and patient outcomes. However, it does not audit IHCAs that are not attended by the resuscitation team.
Critically ill patients managed in ICUs are experiencing failure of one or more organs and therefore more intensive and invasive therapies are needed to support these failing organs. As a result, ICUs have higher nursing and medical staffing ratios, and monitoring is usually continuous. Moreover, the skill mix of the multidisciplinary team is geared to advanced life support. Thus, the risk of cardiac arrest occurring, the involvement (or not) of the resuscitation team, and the probability of return of spontaneous circulation are all likely to be different to other IHCAs.
Accurate data on cardiac arrests in ICU are lacking and the investigators do not know how many IHCA occur in ICU in the UK, nor is the impact of an IHCA in ICU on outcome known. In addition, it is not known if these IHCAs in ICUs represent an unavoidable consequence of critical illness or, more importantly, whether they can be predicted and/or prevented.
CIRCA is a prospective, multi-centre observational cohort study nested in the Case Mix Programme (CMP) and NCAA national clinical audits. The investigators aim to determine the incidence and outcomes of IHCA in UK ICUs and explore associated risk factors with ICU and hospital survival and quality of survival following hospital discharge.
965 studies on the registry are indexed under Heart Arrest; 226 are open to participants now.
This study's planned enrollment of 1,800 is above the median of 200 across 382 observational studies indexed under Heart Arrest.
Browse Heart Arrest studies →Intensive Care National Audit & Research Centre is the lead sponsor of 8 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults having cardiac arrest (defined as receipt of chest compressions and/or defibrillation) after admission to an Intensive Care Unit (ICU) participating in the Case Mix Programme in a hospital participating in the National Cardiac Arrest Audit
Exclusion Criteria:
There are no exclusion criteria
Those experiencing a critical illness-related cardiac arrest in a participating adult, general ICU
Incidence
Incidence of critical illness related cardiac arrest
Time frame: Up to 12 months
Subsequent incidence of in-hospital cardiac arrest
Subsequent incidence of in-hospital cardiac arrest obtained through data linkage to the National Cardiac Arrest Audit
Time frame: Up to 12 months
Survival status at hospital discharge
Survival status at hospital discharge obtained from data linkage to the Case Mix Programme
Time frame: Up to 12 months
Survival status at 12 months
Survival status at 12 months obtained from data linkage to NHS Digital
Time frame: 12 months
Patient quality of life measured through EQ-5D-5L questionnaire completion at 3 months
Patient quality of life measured through completion of EuroQol 5 Dimension (5 level) questionnaire at 3 months following critical illness related cardiac arrest
Time frame: 3 months
Patient quality of life measured through EQ-5D-5L questionnaire completion at 6 months
Patient quality of life measured through completion of EuroQol 5 Dimension (5 level) questionnaire at 6 months following critical illness related cardiac arrest
Time frame: 6 months
Patient quality of life measured through EQ-5D-5L questionnaire completion at 12 months
Patient quality of life measured through completion of EuroQol 5 Dimension (5 level) questionnaire at 12 months following critical illness related cardiac arrest
Time frame: 12 months
Patient quality of life measured through IQCODE questionnaire completion at 3 months
Patient quality of life measured through completion of Informant Questionnaire on Cognitive Decline in the Elderly questionnaire at 3 months following critical illness related cardiac arrest
Time frame: 3 months
Patient quality of life measured through IQCODE questionnaire completion at 6 months
Patient quality of life measured through completion of Informant Questionnaire on Cognitive Decline in the Elderly questionnaire at 6 months following critical illness related cardiac arrest
Time frame: 6 months
Patient quality of life measured through IQCODE questionnaire completion at 12 months
Patient quality of life measured through completion of Informant Questionnaire on Cognitive Decline in the Elderly questionnaire at 12 months following critical illness related cardiac arrest
Time frame: 12 months
Family member quality of life measured through FROM-16 questionnaire completion at 3 months
Quality of life of family member of patients surviving critical illness related cardiac arrest measured through completion of Family Reported Outcome Measures 16 questionnaire at 3 months following patient arrest
Time frame: 3 months
Family member quality of life measured through FROM-16 questionnaire completion at 6 months
Quality of life of family member of patients surviving critical illness related cardiac arrest measured through completion of Family Reported Outcome Measures 16 questionnaire at 6 months following patient arrest
Time frame: 6 months
Family member quality of life measured through FROM-16 questionnaire completion at 12 months
Quality of life of family member of patients surviving critical illness related cardiac arrest measured through completion of Family Reported Outcome Measures 16 questionnaire at 12 months following patient arrest
Time frame: 12 months
Plan to share: Yes — An anonymised study dataset will be available from ICNARC on request to the Chief Investigator, subject to any necessary approvals
No publications or documents are linked to this record.
This study is status unknown, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Intensive Care National Audit & Research Centre